Sahar Poudineh; Alireza Sarlak; Shima Mohamadian; Siamak Najafi; Esmaeil Behzadi; Maryam Poudineh
Abstract
Background: Infertility causes social and psychological distress and has negative economic effects on healthcare systems. Infertility is the incapability to conceive after at least 12 months of unprotected regular sexual intercourse. Finding the impacts of herbal antioxidants can result in new visions ...
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Background: Infertility causes social and psychological distress and has negative economic effects on healthcare systems. Infertility is the incapability to conceive after at least 12 months of unprotected regular sexual intercourse. Finding the impacts of herbal antioxidants can result in new visions for enhancing male fertility. Quercetin belongs to the bioflavonoids family, and many nutritionists, scientists, and researchers have investigated its pharmacokinetic and pharmacodynamic properties in their studies.Methods: In this review, the authors summarized the protecting role of quercetin against oxidative damage and toxic metals stimulating male infertility by searching in PubMed, Web of Science, Scopus, and Embase via the keywords “male infertility”, “quercetin”, “male fertility”, “oxidative stress”, “toxic metals”, “environmental contaminants”, and “heavy metals” without language or date restrictions.Results: Due to insufficient antioxidant defenses and inadequate cell repair systems, spermatozoa are predominantly susceptible to oxidative stress and toxic agents, especially heavy metals. Reactive oxygen species mediate several other cellular mechanisms, such as apoptosis. Previous research has highlighted quercetin and polyphenols’ positive and negative impact on male fertility.Conclusion: Quercetin exerts its beneficial functions through its antioxidant capacity by scavenging ROS and chelating toxic heavy metals and other environmental contaminants; thus, it can prevent male infertility.
Zohreh Mazloom; Seyedeh Maryam Abdollahzadeh; Mohammad Hossein Dabbaghmanesh; Abbas Rezaianzadeh
Volume 2, Issue 1 , January 2014, , Pages 8-14
Abstract
Background: Diabetes Mellitus (DM) is closely associated with reduction of antioxidant defense system. In the present study, we investigated the antioxidant effect of quercetin supplementation on the glycemic control, lipid profile and oxidative stress indices in patients with type 2diabetes. Methods: ...
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Background: Diabetes Mellitus (DM) is closely associated with reduction of antioxidant defense system. In the present study, we investigated the antioxidant effect of quercetin supplementation on the glycemic control, lipid profile and oxidative stress indices in patients with type 2diabetes. Methods: Forty seven patients with type 2 diabetes, aged 30-60 years old, were randomly assigned to supplement their daily diet with either an oral quercetin (250 mg/d) or identical placebo (cellulose) capsules for 8 weeks. The supplements were provided to the patients biweekly. Anthropometric data as well as glycemic indices, lipid profile and oxidative stress parameters of blood samples were determined at the baseline and endpoint of the study. Results: Dietary quercetin supplementation significantly improved the total antioxidant capacity (TAC) in the intervention group, when compared to the placebo group (P=0.043). It also resulted in a statistically significant reduction in serum concentration of atherogenic oxidized LDL (ox-LDL) (P0.05). Conclusions: Oral quercetin supplementation was beneficial in improving the antioxidant status of patients with type 2 diabetes while having no other significant effect on glycemic control and lipid profile; however, conducting further studies, using different doses, on the glycemiccontrol and/or hyperlipidemia of thepopulation seems to be valuable. Trial Registration Number: IRCT2012101911168N