Farhang Hooshmand; Vahid Rahmanian; Mohammad Shojaei; Karamatollah Rahmanian
Abstract
Background: The overall prevalence of metabolically unhealthy (MU) phenotype in Iranian adults is a matter of debate. This study aimed to estimate the prevalence and determinants of metabolically unhealthystate in people over 30 years old in the general population in Southern Iran.Methods: In this cross-sectional ...
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Background: The overall prevalence of metabolically unhealthy (MU) phenotype in Iranian adults is a matter of debate. This study aimed to estimate the prevalence and determinants of metabolically unhealthystate in people over 30 years old in the general population in Southern Iran.Methods: In this cross-sectional population-based study, 891 participants aged ≥30 were selected using a multi-stage cluster sampling method. The study examined age, sex, education, marital status, smoking behavior, weight, height, blood pressure, fasting blood sugar, and lipid profiles. MU was defined as the existence of at least two of four constituents of metabolic abnormalities based on ATP III criteria. Data analysis was carried out in Stata version 14. Finally, a logistic regression was performed to identify the risk factors for MU prevalence.Results: The overall prevalence of MU was 49.4%, corresponding to 37.5%, 55.6%, and 60.2% of normal weight, overweight, and obese participants, respectively. MU prevalence significantly increased from 30.6% in participants aged 30-39 years to 69.7% in participants aged 60 years or older. The results of multivariate logistic regression showed that dyslipidemia (OR=2.98, CI95%:2.13-4.16), high LDL (OR=2.73, CI95%:1.77-4.20), obesity (OR=2.83, CI95%:1.84-4.36), overweight (OR=2.13, CI95%:1.53- 2.98), and higher age (OR=1.04, CI95%:1.03-1.05) was positively associated with the MU state.Conclusion: Metabolically unhealthy state is a public health problem in the study area. In terms of public health, screening for obesity and other metabolic disorders should be regularly performed in clinical practice to take appropriate preventive measures.
Zohreh Mazloom; Seyedeh Maryam Abdollahzadeh; Mohammad Hossein Dabbaghmanesh; Abbas Rezaianzadeh
Volume 2, Issue 1 , January 2014, , Pages 8-14
Abstract
Background: Diabetes Mellitus (DM) is closely associated with reduction of antioxidant defense system. In the present study, we investigated the antioxidant effect of quercetin supplementation on the glycemic control, lipid profile and oxidative stress indices in patients with type 2diabetes. Methods: ...
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Background: Diabetes Mellitus (DM) is closely associated with reduction of antioxidant defense system. In the present study, we investigated the antioxidant effect of quercetin supplementation on the glycemic control, lipid profile and oxidative stress indices in patients with type 2diabetes. Methods: Forty seven patients with type 2 diabetes, aged 30-60 years old, were randomly assigned to supplement their daily diet with either an oral quercetin (250 mg/d) or identical placebo (cellulose) capsules for 8 weeks. The supplements were provided to the patients biweekly. Anthropometric data as well as glycemic indices, lipid profile and oxidative stress parameters of blood samples were determined at the baseline and endpoint of the study. Results: Dietary quercetin supplementation significantly improved the total antioxidant capacity (TAC) in the intervention group, when compared to the placebo group (P=0.043). It also resulted in a statistically significant reduction in serum concentration of atherogenic oxidized LDL (ox-LDL) (P0.05). Conclusions: Oral quercetin supplementation was beneficial in improving the antioxidant status of patients with type 2 diabetes while having no other significant effect on glycemic control and lipid profile; however, conducting further studies, using different doses, on the glycemiccontrol and/or hyperlipidemia of thepopulation seems to be valuable. Trial Registration Number: IRCT2012101911168N
