Document Type: Original Articles

Authors

1 Department of Nutrition, School of Health and Nutrition, Ahvaz University of Medical Sciences, Ahvaz, Iran;

2 Faculty of Nutrition, School of Health and Nutrition, Ahvaz University of Medical Sciences, Ahvaz, Iran;

3 Faculty of Epidemiology and Biostatistics, Ahvaz University of Medical Sciences, Ahvaz, Iran

Abstract

 AbstractBackground: Atherosclerosis and subsequent coronary artery disease is the leading cause of death in Iranian population. High serum lipid levels, especially the elevated level of low-density lipoprotein (LDL), have been shown to be strongly related to the development of atherosclerosis. The relationship between dietary glycemic index (GI) and lipid profile, particularly in nonwestern populations, has not been well studied; also, the result of studies are inconsistent. The aim of this study was to evaluate the relationship between dietary glycemic index (GI) and main risk factor of atherosclerosis including abnormal blood lipid levels in healthy women.Methods: This cross-sectional study was done to investigate the associations between dietary GI and lipid profile. The subjects were 87 female personnel of Ahvaz Jundishapur University of Medical Sciences aged 25-55 y; they were recruited randomly. Dietary GI was calculated from six 24 hour recalls (including 4 usual days and 2 holidays).Results: The mean of dietary GI was 72.1±4.07. After adjustment for potential dietary and non- dietary confounding factors, no significant relationship was found between dietary GI with HDL-C and LDL-C. There was also no statistically significant relationship between GI and total cholesterol or fasting Triacylglycerol.Conclusion: Findings of this study did not support the hypothesis of physiologic relevance of GI and lipid profile abnormality as a potential risk factor for atherosclerosis.

Keywords

  1. References
  2. Hatmi ZN, Tahvildari S, Gafarzadeh Motlag A, Sabouri Kashani A. Prevalence of coronary artery disease risk factors in Iran. BMC Cardiovascular Disorders 2007; 7: 32.
  3. Kromhout D, Menotti A, Kesteloot H, Sans S. Prevention of Coronary Heart Disease by Diet and Lifestyle Evidence From Prospective Cross-Cultural, Cohort, and Intervention Studies. Circulation 2002; 105: 893-8.
  4. Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielden H, Baldwin JM, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 1981; 34: 362-6.
  5. Jenkins DJ, Kendall CW, Augustin LS, Franceschi S, Hamidi M, Marchie A, et al. glycemic index :overview of implication in health and disease . Am J Clin Nutr 2002; 76(1): 266-73.
  6. Jenkins DJ, Wolever TM, Collier GR, Ocana A, Rao AV, Buckley G, et al. Meta bolic effects of a low-glycemicindex diet. Am J Clin Nutr 1987; 46(6): 968-75.
  7. David S. Ludwig, The Glycemic Index Physiological Mechanisms Relating to Obesity, Diabetes, and Cardiovascular Disease. JAMA 2002; 287: 2414-23.
  8. Thomas DE, Elliott EJ, Baur L. low glycemic index or low glycemic load diets for overweight and obesity. Cochrane Database Syst Rev 2007; 3: 254-9.
  9. Amano Y, Kawakubo K, Lee JS, Tang AC, Sugiyama M, Mori K. Correlation between dietary glycemic index and risk factors among Japanese women. Eur J Clin Nutr 2004; 58(11): 1472-8.
  10. Murakami K, Sasaki S, Takahashi Y, Okubo H, Hosoi Y, Horiguchi H, et al. Dietary glycemic index and load in relation to metabolic risk factors. Am J Clin Nutr 2006; 83(5): 1161-9.
  11. Mirmiran Parvin, Saidpor Atosa, Niazi Somaye, Azizi Fereidon. Correlation between dietary glycemic index and glycemic load and metabolic syndrome. Iran Endocrine and Metabolism Journal 2009; 6: 615-25.
  12. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
  13. Taleban A, Esmayili M. Glycemic index of Iranian food. Tehran: National nutrition & food technology research institute publication; 1999.
  14. Foster-Powell K, Holt SH, Brand-Miller JC. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 2002; 76: 5-56.
  15. Wolever TMS, Nguyen PM, Chiasson JL. Relationship between habitual diet and blood glucose and lipids in non-insulin dependent diabetes (NIDDM). Nutr Res 1995; 15: 843-57.
  16. Liu S, Manson JE, Stampfer MJ, Holmes MD, Hu FB, Hankinson SE, et al. Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. Am J Clin Nutr 2001; 73(3): 560-6.
  17. Van Dam RM, Visscher AW, Feskens EJ, Verhoef P, Kromhout D. Dietary glycemic index in relation to metabolic risk factors and inci dence of coronary heart disease: the Zutphen Elderly Study. Eur J Clin Nutr 2000; 54: 726-31.
  18. Frost G, Leeds AA, Dore CJ, Madeiros S, Brading S, Dornhorst A. Glycaemic index as a determinant of serum HDL cholesterol concentration. Lancet 1999; 353(9158): 1045-8.
  19. Ford ES, Liu S. Glycemic index and serum high-density lipoprotein cholesterol concentration among us adults. Arch Intern Med 2001; 161: 572-6.
  20. Shikany JM, Phadke RP, Redden DT, Gower BA. Effects of low- and high-glycemic index/glycemic load diets on coronary heart disease risk factors in overweight/obese men. Metabolism 2009; 58: 1793-801.
  21. Zhang Z, Lanza E, Kris-Etherton PM, Colburn NH, Bagshaw D, Rovine M, et al. A high legume low glycemic index diet improves serum lipid profiles in men. Lipids 2010; 45(9): 767-75.
  22. Raatz SK, Torkelson CJ, Redmon JB, Reck KP, Kwong CA, Swanson J, et al. Reduced glycemic index and glycemic load diets do not increase the effects of energy restriction on weight loss and insulin sensitivity in obese men and women. J Nutr 2005; 135: 2387-91.
  23. Solomon TP, Haus JM, Kelly KR, Cook MD, Filion J, Rocco M, et al. low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulin tropic polypeptide responses in obese, prediabetic humans. Am J Clin Nutr 2010; 92: 1359-68.
  24. Malin SK, Niemi N, Solomon TP, Haus JM, Kelly KR, Filion J, et al. Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults. Ann Nutr Metab 2012; 61(2): 135-41.
  25. Brand-Miller JC. Glycemic load and chronic disease. Nutr Rev 2003; 61: 49-55.
  26. Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995; 75(3): 473-86.