Hossein Safari; Mohammad Hassan Eftekhari; Jafar Hassan Zadeh; Arash Dashtabi
Volume 5, Issue 2 , April 2017, , Pages 59-65
Abstract
Background:Serum vitamin D (VIT D) concentration has been inversely associated with the prevalence of metabolic syndrome (MS), but the relationship has remained unclear. We evaluated the prevalence of VIT D deficiency, and its association with MS, and its components in the adult population in a sunny ...
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Background:Serum vitamin D (VIT D) concentration has been inversely associated with the prevalence of metabolic syndrome (MS), but the relationship has remained unclear. We evaluated the prevalence of VIT D deficiency, and its association with MS, and its components in the adult population in a sunny tropical region (Lamerd: a city in the south of Iran)Patients and Methods: Totally, 210 patients referring to different medical centers across the Lamerd city participated in this cross-sectional study through January and February of 2016. To select medical service center, we used a one-stage cluster sampling method. Anthropometric indices and dietary intake were measured using modified food frequency questionnaire (FFQ) and blood samples collected. Data were analyzed using SPPS version 16, Pearson’s correlation was used to investigate the bivariate relationships between the variables, and unpaired t-test was used to determine the differences between genders for all variables. A P-value < 0.05 was considered statistically significant.Results:Overall, 62 menand 144 womenwith a mean age of 35.84± 10.84 years old completed this study; the prevalence of VIT D deficiency among the participants equaled 64.1% (women=66.7% and men=58.1%). A significant positive relationship between sun exposure time on the serum VIT (p= <0.0015), and a negative relationship between the serum VIT D on triglyceride (p= 0.035), TC (p= 0.025, age (p= 0.001), and fasting blood sugar (p= <0.001) were found.Conclusions: This study showed that lower VIT D concentrations were associated with increased MS risk factors.
Masoumeh Akhlaghi; Majid Kamali; Farideh Dastsouz
Volume 4, Issue 4 , October 2016, , Pages 181-188
Abstract
AbstractBackground: Vitamin D deficiency is implicated in a wide rangeof pathological situations including cardiovascular diseases.This study aimed to investigate the association between serum25-hydroxy vitamin D (25(OH)D) and risk factors of metabolicsyndrome and cardiovascular diseases.Methods: The ...
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AbstractBackground: Vitamin D deficiency is implicated in a wide rangeof pathological situations including cardiovascular diseases.This study aimed to investigate the association between serum25-hydroxy vitamin D (25(OH)D) and risk factors of metabolicsyndrome and cardiovascular diseases.Methods: The cross-sectional study was conducted on 169adults (88 males, 81 females) aged 19-52 years living in Shiraz,Iran. Anthropometric characteristics and blood pressure weremeasured using standard methods. Blood samples were collectedin fasting state for determination of blood glucose, lipids, and25(OH)D. Data were analyzed with one-way analysis of varianceand linear regression using SPSS software.Results: Serum 25(OH)D concentrations were considerablyhigher in males. One third of females had vitamin D deficiency(25(OH)D <10 ng/ml) while one third of males exhibited25(OH)D levels >50 ng/ml. In males, systolic and diastolicblood pressure, triglycerides, and metabolic syndrome scoreincreased and high-density lipoprotein (HDL) cholesteroldecreased across tertiles of serum 25(OH)D. On the contrary,in females body mass index (BMI) and metabolic syndromescore decreased and HDL cholesterol increased across tertilesof 25(OH)D. Linear regression, after controlling for confoundingfactors, showed that diastolic blood pressure (B=0.07; 95% CI:0.02, 0.11; P=0.006), triglycerides (B=0.54; 95% CI: 0.22, 0.85;P=0.001), and metabolic syndrome score (B=0.01; 95% CI: 0.001,0.01; P=0.02) positively and HDL cholesterol (B=-0.05; 95% CI:-0.09, -0.01; P=0.02) inversely associated with tertiles of 25(OH)D concentrations in males. In contrast, BMI (B=-0.06; 95% CI:-0.11, -0.02; P=0.01), waist circumference (B= -0.12; 95% CI:-0.23, -0.01; p=0.04), and metabolic syndrome score (B=-0.02;95% CI:-0.03, -0.01; P=0.01) were inversely and HDL-C (B=0.16;95% CI: 0.02, 0.31; P=0.02) positively associated with 25(OH)D tertiles in females.Conclusion: The results suggest that both low and uppernormal levels of 25(OH)D are associated with increased risk ofcardiovascular diseases and metabolic syndrome.
