Journal of Health Sciences & Surveillance System

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

News

Comparison of Neuropsychological Functioning among Individuals Diagnosed with Bipolar Disorder with and without Childhood ADHD

Document Type : Original Article

Authors

1 Research Center for Psychiatry and Behavior Sciences Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Psychology, Shiraz Branch, Islamic Azad University, Shiraz, Iran

Abstract

Background: Bipolar mood disorder (BMD) with a lifetime history of Attention-deficit hyperactivity disorder (ADHD) characterized by a particularly neuropsychological profile. This study aimed to clarify whether there is a difference between BMD patients with ADHD and BMD patients without ADHD in terms of neuropsychological functioning.
Methods: This is a cross-sectional study with 68 samples (24 patients had BMD with ADHD and 44 patients had BMD) selected based on the target sampling during a year (March 2014 to March 2015). Tower of London (ToL) task, Conners’ Continuous Performance Test (CPT), and Wisconsin Card Sorting Test (WCST) were used for assessing neuropsychological functioning in participants. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) version 16 software.
Results: The results revealed that the BMD with ADHD group was not more impaired than the BMD group on two measures of executive functioning TOL and CPT. The BMD in the ADHD group was more impaired than the BMD group on WCST.
Conclusion: This study will be effective in understanding whether the cognitive flexibility impairments often detected in adult BMD are partially the result of lifetime ADHD.

Highlights

Arash Mani (Google Scholar)

Leila Khabir (Google Scholar)

Keywords

References
  1. del Mar Bonnín C, Reinares M, Martínez-Arán A, Jiménez E, Sánchez-Moreno J, Solé B, Montejo L, Vieta E. Improving functioning, quality of life, and well-being in patients with bipolar disorder. 2019; 22(8): 467-77. doi: 10.1093/ijnp/pyz018.
  2. Sui SX, Balanta-Melo J, Pasco JA, Plotkin LI. Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms. Curr Osteoporos Rep. 2022. doi: 10.1007/s11914-022-00736-9.
  3. American Psychiatric Association, 2013. Diagnostic and Statistical Manual of Mental Disorders (DSM-5). American Psychiatric Pub.
  4. Pinzonea V, DeRossia P, Trabucchia G, Lesterd D, Girardia P, Pompilia M. Temperament correlates in adult ADHD: A systematic review. JournalofAffectiveDisorders. 2019; 2052: 394-403. doi: 10.1016/j.jad.2019.04.006.
  5. Marangoni C, De Chiara L, Faedda GL. Bipolar disorder and ADHD: comorbidity and diagnostic distinctions. Curr Psychiatry Rep. 2015; 19. doi: 10.1007/s11920-015-0604-y.
  6. Irwin LN, Kofler MJ, Soto EF, Groves NB. Do children with attention-deficit/hyperactivity disorder (ADHD) have set shifting deficits? Neuropsychology. 2019; 33(4): 470-81. doi:10.1037/neu0000546.
  7. Luo Y, Weibman D, Halperin JM, Li X. A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD). Frontiers in human neuroscience, 2019; 13: 42. doi: 10.3389/fnhum.2019.00042.
  8. Mckenzie A, Meshkat S, Lui LMW, Ho R, Di Vincenzo JD, Ceban F, Cao B, McIntyre RS. The effects of psychostimulants on cognitive functions in individuals with attention-deficit hyperactivity disorder: A systematic review. J Psychiatr Res. 2022; 149: 252-9. doi: 10.1016/j.jpsychires.2022.03.018.
  9. Torres I, Sole B, Corrales M, Jiménez E, Rotger S, Serra-Pla JF, et al. Are patients with bipolar disorder and comorbid attention-deficit hyperactivity disorder more neurocognitively impaired? Bipolar Disord. 2017; 19: 637-50. doi: 10.1111/bdi.12540.
  10. Salarvan S, Sparding T, Clements C, Rydén E, Landén M. Neuropsychological profiles of adult bipolar disorder patients with and without comorbid attention-deficit hyperactivity disorder. Int J Bipolar Disord. 2019; 7(14). doi: 10.1186/s40345-019-0149-9.
  11. Passarotti AM, Trivedi N, Dominguez-Colman L, Patel M, Langenecker SA. Differences in Real World Executive Function between Children with Pediatric Bipolar Disorder and Children with ADHD. Journal of the Canadian Academy of Child and Adolescent Psychiatry. 2016; 25(3):185-195. PMID: 27924149; PMCID: PMC5130092.
  12. Silva KL, Rovaris DL, Guimarães-da-Silva PO, Victor MM, Salgado CA, Vitola ES, et al. Could comorbid bipolar disorder account for a significant share of executive function deficits in adults with attention-deficit hyperactivity disorder? Bipolar Disord. 2014; 16:270–6. doi: 10.1111/bdi.12158.
  13. Rucklidge JJ. Impact of ADHD on the neurocognitive functioning of adolescents with bipolar disorder. Biol Psychiat. 2006; 60: 921–8. doi: 10.1016/j.biopsych.2006.03.067.
  14. Feldstein S, Keller F, Portman R, Durham R, Klebe K, Davis H. A Comparison of Computerized and Standard Versions of the Wisconsin Card Sorting Test. The Clinical neuropsychologist. 1999; 13: 303-313. doi: 10.1076/clin.13.3.303.1744.
  15. Dias NM, Seabra AG. Executive demands of the Tower of London task in Brazilian teenagers. Psychol. Neurosci. 2012; 5(1): 63-75. doi: 10.3922/j.psns.2012.1.09.
  16. Shahgholian M, Azadfallah P, Fathi-Ashtiani A, khodadadi M. Design of the Wisconsin Card Sorting Test (WCST) computerized version: Theoretical Fundamental, Developing and Psychometrics Characteristics. Clinical Psychology Studies. 2011; 1(4): 110-134.
  17. Conners CK. Conners’ Continuous Performance Test (CPT-2) computer program for windows, technical guide, and software manual. Toronto, ON: Multi Health Systems Inc. 2000.
  18. Hashemian Nejad F, Veysi N, Shirkavand N, Ashoori J. Comparing the Effectiveness of Neurofeedback Training and Computer Games on Continuous Attention and Planning Ability in Students with Attention Deficit disorder. Arak Medical University Journal (AMUJ). 2015; 18(101): 81-92. http://jams.arakmu.ac.ir/article-1-3626-en.htm.
  19. Kopp B, Lange F, Steinke A. The Reliability of the Wisconsin Card Sorting Test in Clinical Practice. Assessment. 2019. doi: 10.1177/1073191119866257.
  20. Lange F, Kip A, Klein T, Müller D, Seer C, Kopp B. Effects of rule uncertainty on cognitive flexibility in a card-sorting paradigm. Acta psychologica. 2018; 190. 53-64. doi: 10.1016/j.actpsy.2018.07.002.
  21. Ferrero A, Rossi M. Cognitive profile and neuropsychiatric disorders in Becker muscular dystrophy: A systematic review of literature. Neurosci Biobehav Rev. 2022; 137. doi: 10.1016/j.neubiorev.2022.104648.
  22. Tehrani-Doost M, Soleimannejad M, Khorrami A, Yoosefee S. Comparison of Continuous Performance Test Results of Former Morphine and Methamphetamine Users During the Early Abstinence Phase, Iran J Psychiatry Behav Sci. 2018; 12(3): e57233. doi: 10.5812/ijpbs.57233.
  23. Sparding T, Silander K, Palsson E, Östlind J, Sellgren C, Ekman CJ, et al. Cognitive functioning in clinically stable patients with bipolar disorder I and II. PLoS ONE. 2015;10: e0115562. doi: 10.1371/journal.pone.0115562.
  24. Robinson LJ, Ferrier IN. Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence. Bipolar Disord. 2006; 8:103–16. doi: 10.1111/j.1399-5618.2006.00277.x.
  25. Torres IJ, Boudreau VG, Yatham LN. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis. Acta Psychiatr Scand Suppl. 2007; 116:17–26. doi: 10.1111/j.1600-0447.2007.01055.x.
  26. Arts B, Jabben N, Krabbendam L, Van Os J. Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med. 2008; 38:771–85. doi: 10.1017/S0033291707001675.
  27. Bourne C, Aydemir O, Balanzá-Martínez V, Bora E, Brissos S, Cavanagh JTO, et al. Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: An individual patient data meta-analysis. Acta Psychiatr Scand. 2013; 128:149–62. doi: 10.1111/acps.12133.
  28. Hervey AS, Epstein JN, Curry JF. Neuropsychology of adults with attention-deficit/hyperactivity disorder: A meta-analytic review. Neuropsychology. 2004; 18:485–503. doi: 10.1037/0894-4105.18.3.485.
  29. Schoechlin C, Engel RR. Neuropsychological performance in adult attention-deficit hyperactivity disorder: meta-analysis of empirical data. Arch Clin Neuropsychol. 2005; 20:727–44. doi: 10.1016/j.acn.2005.04.005.
  30. Burdick KE, Russo M, Frangou S, Mahon K, Braga RJ, Shanahan M, et al. Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: Clinical implications. Psychol Med. 2014; 44:3083–96. doi: 10.1017/S0033291714000439.
  31. Bora E, Hıdıroğlu C, Özerdem A, Kaçar ÖF, Sarısoy G, Civil Arslan F, et al. Executive dysfunction and cognitive subgroups in a large sample of euthymic patients with bipolar disorder. Eur Neuropsychopharmacol. 2016; 26:1338–477. doi: 10.1016/j.euroneuro.2016.04.002.
  32. Sparding T, Silander K, Pålsson E, Östlind J, Ekman CJ, Sellgren CM, et al. Classification of cognitive performance in bipolar disorder. Cognitive Neuropsychiatry. 2017; 22:407–21. doi: 10.1080/13546805.2017.1361391.
  33. Roger SM, Joseph RC. Bipolar depression: the clinical characteristics and unmet needs of a complex disorder, Current Medical Research and Opinion. 2019; 35:11, 1993-2005, doi: 10.1080/03007995.2019.1636017.
Journal of Health Sciences & Surveillance System
Volume 12, Issue 2
April 2024
Pages 179-184
Files
Share
How to cite
Statistics