Hamidreza Tabatabaee; Parvin Afsar-kazerooni; Yousef Alimohamadi; Alireza Hasanabadi; Fatemeh Khavandegaran; Katayoun Tayeri; Abbas Rezaianzadeh; Jafar Hasanzadeh
Volume 3, Issue 1 , January 2015, , Pages 13-19
Abstract
Background: Intensified strategy includes special attention to the symptoms such as cough (more than two weeks), fever (more than three weeks), night sweats (more than three weeks), and weight loss (more than 3 kg per month). If any of the above symptoms was positive, in suspected individuals for TB, ...
Read More
Background: Intensified strategy includes special attention to the symptoms such as cough (more than two weeks), fever (more than three weeks), night sweats (more than three weeks), and weight loss (more than 3 kg per month). If any of the above symptoms was positive, in suspected individuals for TB, more assessment should be done. The aim of this study was to compare between intensified and routine case finding for a better case selection method for diagnosis of pulmonary tuberculosis among HIV-Infected Persons.Methods: The sample size was calculated 237 patients (474 for the two groups). In the current study, the patients were divided randomly into two groups: A) intensified case finding group and B) routine case finding group. Considering the sputum culture as the gold standard, we calculated the sensitivity and specificity, Positive predictive value (PPV), Negative predictive value (NPV) for fever, weight loss, coughing more than two week, night sweats, and PPD test.Result: A total of eight positive cases of tuberculosis were detected in the intensified while four were found in the routine case finding group. Sensitivity, specificity, PPV, and NPV for cough in diagnosis of TB were 25%, 87%, 6%, and 97%, respectively. For weight loss, they were 62.5%, 83%, 10.8%, and 98.5% respectively while these amounts were, 7%, 85%, 97.6, 37.5 for night sweats. For fever, they were, 25%, 92.9%, 10.5%, and 97% respectively, and for PPD they were 87.5%, 40%, 4.6%, and 98.9%, respectively.Conclusion: Key symptom screening, such as cough, fever, weight loss and night sweats, has an important role in detecting TB among HIV-infected patients.
Zohreh Mazloom; Seyedeh Maryam Abdollahzadeh; Mohammad Hossein Dabbaghmanesh; Abbas Rezaianzadeh
Volume 2, Issue 1 , January 2014, , Pages 8-14
Abstract
Background: Diabetes Mellitus (DM) is closely associated with reduction of antioxidant defense system. In the present study, we investigated the antioxidant effect of quercetin supplementation on the glycemic control, lipid profile and oxidative stress indices in patients with type 2diabetes. Methods: ...
Read More
Background: Diabetes Mellitus (DM) is closely associated with reduction of antioxidant defense system. In the present study, we investigated the antioxidant effect of quercetin supplementation on the glycemic control, lipid profile and oxidative stress indices in patients with type 2diabetes. Methods: Forty seven patients with type 2 diabetes, aged 30-60 years old, were randomly assigned to supplement their daily diet with either an oral quercetin (250 mg/d) or identical placebo (cellulose) capsules for 8 weeks. The supplements were provided to the patients biweekly. Anthropometric data as well as glycemic indices, lipid profile and oxidative stress parameters of blood samples were determined at the baseline and endpoint of the study. Results: Dietary quercetin supplementation significantly improved the total antioxidant capacity (TAC) in the intervention group, when compared to the placebo group (P=0.043). It also resulted in a statistically significant reduction in serum concentration of atherogenic oxidized LDL (ox-LDL) (P0.05). Conclusions: Oral quercetin supplementation was beneficial in improving the antioxidant status of patients with type 2 diabetes while having no other significant effect on glycemic control and lipid profile; however, conducting further studies, using different doses, on the glycemiccontrol and/or hyperlipidemia of thepopulation seems to be valuable. Trial Registration Number: IRCT2012101911168N