Mohammad Jalali; Michael E Symonds; Morteza Zare; Zahra Sohrabi
Abstract
Background: Heart failure (HF) is a clinical disorder and Zinc is an important cofactor in regulating oxidative status.The present study aimed to determine the mean concentration of serum zinc in patients with HF.
Methods: PubMed, Embase, Scopus, and Web of Science were used in the present systematic ...
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Background: Heart failure (HF) is a clinical disorder and Zinc is an important cofactor in regulating oxidative status.The present study aimed to determine the mean concentration of serum zinc in patients with HF.
Methods: PubMed, Embase, Scopus, and Web of Science were used in the present systematic review and meta-analysis to find relevant cross-sectional studies up to 1st January 2020. A random-effects model was used to pool the effect size (ES) and 95 % confidence intervals (CI). In addition, meta-regression analysis was performed to find the sources of statistical heterogeneity among the studies.
Results: Our meta-analysis of 1358 HF patients indicated that their mean serum zinc concentration was 66.24 µg/dl (95 % CI: 59.16, 73.33). In sub-analysis, the mean concentration was 75.04 µg/dl and 52.90 µg/dl in patients < 65 years and > 65 years old, respectively. Subgroup analysis by geographical region showed that mean serum zinc was 70.70 µg/dl, 69.08 µg/dl and 60.91 µg/dl in HF patients from Europe, America, and Asia, respectively. Meta-regression analysis indicated a reduction of 1.42 µg/dl in serum zinc per each year of aging.
Conclusion: In summary, our meta-analysis indicates that serum zinc concentrations have a narrow range in HF patients worldwide that declines with age and varies with geographical region. Additionally, serum zinc concentrations are lower in HF patients, specifically in the elderly.
Hassan Hashemi; Abbas Khodabakhshi; Bahram Alinia; Fariba Abbasi
Abstract
Background: This study investigated the bioremediation of lead and zinc in contaminated soils by the compost worm Eisenia Fetida. Methods: The initial concentrations of 50 and 100 mg/kg for zinc and lead respectively as well as 40 mg/kg and 80 mg/kg for the control group were studied. 30 earthworms were ...
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Background: This study investigated the bioremediation of lead and zinc in contaminated soils by the compost worm Eisenia Fetida. Methods: The initial concentrations of 50 and 100 mg/kg for zinc and lead respectively as well as 40 mg/kg and 80 mg/kg for the control group were studied. 30 earthworms were used for bioremediation of 500g samples of the polluted soils during 14 and 28 days. Then, Pb and Zn were measured by atomic absorption kit (Varian 240) in the soil and earthworm’s tissue. Results: The mortality rate of earthworms was insignificant statistically, so that it was lower than 20% when exposed to 86 mg/L of lead. Moreover, the removal efficiency of Pb and Zn was higher than 90% in th soil. Initial concentration of Pb and Zn was 3 and 6 mg/kg and the bioaccumulation was 0.16 and 32 μg/g respectively during 14 days, while they were 0.31 and 59 μg/g at the end of 28 days. The removal efficiency of Pb and Zn was increased as the exposure time and concentration of Pb and Zn in the earthworm bodies increased. Conclusion: As a consequence, the use of earthworms is an appropriate organic and cost-effective method for bioremediation of Pb and Zn significantly. However, the improvement and modification of bioaccumulation in earthworm bodies is an environmental challenge that should be managed.