Mohammad Jalali; Michael E Symonds; Morteza Zare; Zahra Sohrabi
Abstract
Background: Heart failure (HF) is a clinical disorder and Zinc is an important cofactor in regulating oxidative status.The present study aimed to determine the mean concentration of serum zinc in patients with HF.
Methods: PubMed, Embase, Scopus, and Web of Science were used in the present systematic ...
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Background: Heart failure (HF) is a clinical disorder and Zinc is an important cofactor in regulating oxidative status.The present study aimed to determine the mean concentration of serum zinc in patients with HF.
Methods: PubMed, Embase, Scopus, and Web of Science were used in the present systematic review and meta-analysis to find relevant cross-sectional studies up to 1st January 2020. A random-effects model was used to pool the effect size (ES) and 95 % confidence intervals (CI). In addition, meta-regression analysis was performed to find the sources of statistical heterogeneity among the studies.
Results: Our meta-analysis of 1358 HF patients indicated that their mean serum zinc concentration was 66.24 µg/dl (95 % CI: 59.16, 73.33). In sub-analysis, the mean concentration was 75.04 µg/dl and 52.90 µg/dl in patients < 65 years and > 65 years old, respectively. Subgroup analysis by geographical region showed that mean serum zinc was 70.70 µg/dl, 69.08 µg/dl and 60.91 µg/dl in HF patients from Europe, America, and Asia, respectively. Meta-regression analysis indicated a reduction of 1.42 µg/dl in serum zinc per each year of aging.
Conclusion: In summary, our meta-analysis indicates that serum zinc concentrations have a narrow range in HF patients worldwide that declines with age and varies with geographical region. Additionally, serum zinc concentrations are lower in HF patients, specifically in the elderly.
Zahra Mousavi-Shirazi-Fard; zohreh mazloom; Mohammad Jalali; Naeimehossadat Asmarian; Mohammad Hossein Dabbaghmanesh; Mahmood Panahiyan
Abstract
Objective: Individualized Medical Nutrition Therapy (IMNT) is recommended as a part of glycemic control in hospitalized diabetic patients. However, it is provided only for a small number of patients. This study aimed to compare the effects of IMNT and Consistent Carbohydrate Meal-Planning (CCMP) on glycemic ...
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Objective: Individualized Medical Nutrition Therapy (IMNT) is recommended as a part of glycemic control in hospitalized diabetic patients. However, it is provided only for a small number of patients. This study aimed to compare the effects of IMNT and Consistent Carbohydrate Meal-Planning (CCMP) on glycemic control, energy, and carbohydrate and protein intake in hospitalized diabetic patients. Methods: This randomized clinical trial was conducted on 164 hospitalized diabetic patients. The patients were randomly selected from internal wards of Namazi hospital, Shiraz, Iran from September 2016 to October 2017. They were allocated to IMNT or CCMP groups using simple randomization for four days. Blood glucose was measured before each meal and at bedtime. A 24-h food recall was also completed to measure the energy and carbohydrate and protein intake during the study. The data were analyzed using independent sample t-test and repeated measures ANOVA via the SPSS software, version 19. Results: The results showed a significant decrease in the IMNT group compared to the CCMP group regarding the mean blood glucose level measured prior to breakfast, lunch, dinner, and bedtime during the first, second, third, and fourth days of the study (p=0.025, p=0.030, p=0.002, and p=0.011, respectively). Besides, mean peak and nadir of glucose level (p=0.042 and p=0.036, respectively) and the means of energy, carbohydrate, and protein intake were significantly increased in the IMNT group compared to the CCMP group. Conclusion: IMNT could help to control the blood glucose. In addition, it could improve energy and nutrients intake, which might play a role in patient recovery.
