Comparison of metabolic syndrome components, inflammation and oxidative stress indices in normal weight obese and normal weight women: A case- control study

Eftekhari, Mohammad Hassan; Ranjbar Zahedani, Maryam; Kohansal, Atefeh

doi:10.30476/jhsss.2019.84627.1036

Document Type : Original Article

Authors

¹ PhD in nutrition sciences, Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

² PhD candidate in nutrition sciences, Student research committee, Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

³ MSc student in nutrition sciences, Student research committee, Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

https://doi.org/10.30476/jhsss.2019.84627.1036

Abstract

Background: Normal Body Mass Index (BMI) = 18.5-24.9 kg/m2 and high Body Fat (BF), have been defined as Normal Weigh Obesity (NWO), which can increase the risk of Metabolic Syndrome (MetS) and cardiovascular diseases. The present study aimed to determine the association between NWO and MetS indicators, Insulin Resistance (IR), and inflammatory and oxidative stress indices in NW obese compared to normal weight women referring to Imam Reza medical center, Shiraz, Iran.
Methods: In this case-control study, 41 healthy NW obese Iranian women were recruited and compared to 45 healthy non-obese control subjects. Anthropometric features, body composition, blood pressure, inflammation and oxidative stress indices, fasting insulin, lipid profile, and blood sugar were measured. IR was also assessed by means of special formulas.
Results: The results showed a significant difference between the NWO and the control group regarding anthropometric measurements and body composition, including waist (p=0.008) and hip (p<0.001) circumferences, BF (p<0.001), skeletal muscle (p=0.03), protein(p=0.04), body cell mass(p=0.02), bone mass content(p=0.04), and arm circumference(p<0.001). All subjects had normal systolic and diastolic blood pressures. However, the NWO group showed significantly higher serum concentrations of triglycerides (p=0.02), total cholesterol(p=0.02), and C-reactive protein (p<0.001). On the other hand, the results of McAuley test indicated significantly lower insulin sensitivity in the NWO group (p=0.03). Besides, serum MDA concentration did not have a marked differences in both study groups.
Conclusion:

Keywords

References

1. Grundy SM, Brewer HB, Jr., Cleeman JI, Smith SC, Jr., Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109(3):433-8.

2. Dalvand S, Bakhshi E, Zarei M, Asl MT, Ghanei R. Prevalence of Metabolic Syndrome in Iran: A systematic review and meta-analysis. Medical-Surgical Nursing Journal. 2017;5(4):1-14.

3. Han TS, Lean ME. A clinical perspective of obesity, metabolic syndrome and cardiovascular disease. JRSM cardiovascular disease. 2016;5:2048004016633371.

4. Collazo-Clavell M, Lopez-Jimenez F. Accuracy of body mass index to diagnose obesity in the US adult population. International Journal of Obesity. 2008;32(6):959-66.

5. Okorodudu D, Jumean M, Montori V, Romero-Corral A, Somers V, Erwin P, et al. Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. International journal of obesity. 2010;34(5):791.

6. De Lorenzo A, Bianchi A, Maroni P, Iannarelli A, Di Daniele N, Iacopino L, et al. Adiposity rather than BMI determines metabolic risk. International journal of cardiology. 2013;166(1):111-7.

7. De Lorenzo A, Martinoli R, Vaia F, Di Renzo L. Normal weight obese (NWO) women: an evaluation of a candidate new syndrome. Nutrition, Metabolism and Cardiovascular Diseases. 2006;16(8):513-23.

8. Marques-Vidal P, Pécoud A, Hayoz D, Paccaud F, Mooser V, Waeber G, et al. Prevalence of normal weight obesity in Switzerland: effect of various definitions. European journal of nutrition. 2008;47(5):251.

9. Romero-Corral A, Somers VK, Sierra-Johnson J, Korenfeld Y, Boarin S, Korinek J, et al. Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. European heart journal. 2009;31(6):737-46.

10. de Ferranti S, Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clinical chemistry. 2008;54(6):945-55.

11. De Lorenzo A, Del Gobbo V, Premrov MG, Bigioni M, Galvano F, Di Renzo L. Normal-weight obese syndrome: early inflammation?–. The American journal of clinical nutrition. 2007;85(1):40-5.

12. Karkhaneh M, Taheri E, Qorbani M, Mohajeri Tehrani MR, Hoseini S. ASSESSMENT OF METABOLIC SYNDROME COMPONENTS IN OBESE WOMEN WITH NORMALWEIGHT COMPARED TO NON OBESE HEALTHY WOMEN. Iranian Journal of Diabetes and Metabolism. 2015;14(4):279-86.

13. Lohman TG, Roche AF, Martorell R. Anthropometric standardization reference manual: Human kinetics books Champaign; 1988.

14. Kannan S, Mahadevan S, Ramji B, Jayapaul M, Kumaravel V. LDL-cholesterol: Friedewald calculated versus direct measurement-study from a large Indian laboratory database. Indian journal of endocrinology and metabolism. 2014;18(4):502.

15. Jahromi BN, Dabaghmanesh MH, Parsanezhad ME, Fatehpoor F. Association of leptin and insulin resistance in PCOS: A case-controlled study. International Journal of Reproductive BioMedicine. 2017;15(7):423.

16. Ascaso JF, Romero P, Real JT, Lorente RI, Martı́nez-Valls J, Carmena R. Abdominal obesity, insulin resistance, and metabolic syndrome in a southern European population. European Journal of Internal Medicine. 2003;14(2):101-6.

17. Rexrode KM, Carey VJ, Hennekens CH, Walters EE, Colditz GA, Stampfer MJ, et al. Abdominal adiposity and coronary heart disease in women. Jama. 1998;280(21):1843-8.

18. Lee J, Chung D-S, Kang J-H, Yu B-Y. Comparison of visceral fat and liver fat as risk factors of metabolic syndrome. Journal of Korean medical science. 2012;27(2):184-9.

19. Faria G, Gonçalves A, Cunha R, Guimaraes J, Calhau C, Preto J, et al. Beyond central adiposity: liver fat and visceral fat area are associated with metabolic syndrome in morbidly obese patients. International Journal of Surgery. 2015;14:75-9.

20. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. Jama. 1998;279(18):1477-82.

21. González AS, Guerrero DB, Soto MB, Díaz SP, Martinez-Olmos M, Vidal O. Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin. European journal of clinical nutrition. 2006;60(6):802.

22. Deepa R, Velmurugan K, Arvind K, Sivaram P, Sientay C, Uday S, et al. Serum levels of interleukin 6, C-reactive protein, vascular cell adhesion molecule 1, and monocyte chemotactic protein 1 in relation to insulin resistance and glucose intolerance—the Chennai Urban Rural Epidemiology Study (CURES). Metabolism. 2006;55(9):1232-8.

23. Guldiken S, Demir M, Arikan E, Turgut B, Azcan S, Gerenli M, et al. The levels of circulating markers of atherosclerosis and inflammation in subjects with different degrees of body mass index: soluble CD40 ligand and high-sensitivity C-reactive protein. Thrombosis research. 2007;119(1):79-84.

24. Karelis AD, St-Pierre DH, Conus F, Rabasa-Lhoret R, Poehlman ET. Metabolic and body composition factors in subgroups of obesity: what do we know? The Journal of Clinical Endocrinology & Metabolism. 2004;89(6):2569-75.

25. Madeira FB, Silva AA, Veloso HF, Goldani MZ, Kac G, Cardoso VC, et al. Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country. PloS one. 2013;8(3):e60673.

26. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. The Journal of clinical investigation. 2017;114(12):1752-61.

27. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. Jama. 2012;307(5):491-7.

Journal of Health Sciences & Surveillance System

Comparison of metabolic syndrome components, inflammation and oxidative stress indices in normal weight obese and normal weight women: A case- control study

References

References

Volume 6, Issue 3
July 2018
Pages 116-122

Comparison of metabolic syndrome components, inflammation and oxidative stress indices in normal weight obese and normal weight women: A case- control study

References

References

Volume 6, Issue 3July 2018Pages 116-122

Volume 6, Issue 3
July 2018
Pages 116-122