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Review and A Brief Report on the Health Perspective, Causative Agents, Vectors, and Reservoirs of Visceral Leishmaniasis in Iran

Document Type : Review Articles

Authors

1 Department of Vector Biology and Control of Diseases, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

2 Research Center for Health Sciences, Institute of Health, Department of Vector Biology and Control of Diseases, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

3 Li Ka Shing Center for Health Research and Innovation. University of Alberta, AB, Canada

Abstract

Background: Visceral leishmaniasis (VL) is still widespread in tropical and subtropical regions worldwide. The vector of the disease is a sandfly, when infected with Leishmania parasite, can transmit the parasite from humans to other vertebrates. As knowledge about causative agents, vectors, and reservoirs of VL in Iran is necessary to control the disease, the present review study has focused on the disease elimination status from a health perspective in the country. Methods: In a recent review, various databases, such as Web of Science, PubMed, Scopus, Cochrane Library, Science Direct, Google Scholar, MEDLIB, Irandoc, Magiran, and SID were searched using the keywords “visceral leishmaniasis”, “VL”, “kala-azar”, “causative agent”, “parasite”, “vector”, “reservoir”, and “Iran”, and the retrieved data were extracted and reviewed independently during 2001-2019. Results: 475 published studies were recorded about VL in Iran from 2001 to 2021. 68 articles were later excluded from the study due to duplication after the initial review. Leishmania infantum and L. tropica were the causative agents, and dogs and humans were the reservoirs. The most common vectors were Phlebotomus major, P. kandelakii, P. keshishiani, P. alexandri, P. perfiliewi, and P. tobbi in different country regions. Conclusion: The prospect of eliminating VL in Iran is inadequate. Based on the findings, L. infantum and L. tropica were the causative agents, and humans and the Caninae subfamily were the VL reservoirs in the country. These findings can be added to the literature when health policymakers target preventive measures for VL in Iran.

Keywords

References
  1. Singh S. New developments in diagnosis of leishmaniasis. Indian J Med Res. 2006;123(3):311. PMID: 16778313.
  2. Davoodi T, Khamesipour A, Shahabi S, Gholizadeh F, Pourkamal D, Hatam G. Geographical distribution and molecular epidemiology of cutaneous leishmaniasis in Fars Province, southern Iran. Environ Sci Pollut Res. 2021:16:1-9.
  3. Postigo JAR. Leishmaniasis in the world health organization eastern mediterranean region. Int J Antimicrob Agents. 2010;36:S62-S65. https://doi.org/1016/j.ijantimicag.2010.06.023.
  4. Torres-Guerrero E, Quintanilla-Cedillo MR, Ruiz-Esmenjaud J, Arenas R. Leishmaniasis: a review. F1000Research. 2017;6.
  5. Moshfe A, Mohebali M, Afshoun E, Mousavizadeh A, Zarei Z, Abidi H, et al. Canine Visceral Leishmaniasis in Boyer Ahmad district, Kohgiluyeh & Boyer Ahmad province, southwest of Iran. Iranian J Parasitol. 2012;7(4):75. PMID: 23323094. PMCID: PMC3537473.
  6. Mohebali M. Visceral Leishmaniasis in Iran: review of the epidemiological and clinical features. Iranian J Parasitol. 2013;8(3):348. PMID: 24454426. PMCID: PMC3887234.
  7. Ready PD. Epidemiology of Visceral Leishmaniasis. Clin Epidemiol. 2014;6:147. PMID: 24833919. PMCID: PMC4014360. https://doi.org/2147/CLEP.S44267.
  8. Rezaei Z, Azarang E, Shahabi S, Omidian M, Pourabbas B, Sarkari B. Leishmania ITS1 Is genetically divergent in asymptomatic and symptomatic visceral leishmaniasis: results of a study in southern iran. J Trop Mede. 2020; ID 5351098. https://doi.org/10.1155/2020/5351098.
  9. Najafi L, Omidian M, Rezaei Z, Shahabi S, Ghorbani F, Arefkhah N, Mohebali M, Zaraei Z, Sarkari B. Molecular and serological evaluation of zoonotic visceral leishmaniasis in dogs in a rural area of Fars province, southern Iran, as a source of Leishmania infantum infection. Vet Med Sci. 2021; 7(4):1082-1089.
  10. Daneshbod Y, Oryan A, Davarmanesh M, Shirian S, Negahban S, Aledavood A, Davarpanah MA, Soleimanpoor H, Daneshbod K. Clinical, histopathologic, and cytologic diagnosis of mucosal leishmaniasis and literature review. Arch Pathol Lab Med 2011;135(4):478-82.
  11. Fakhar M, Rahmati B. Visceral Leishmaniasis in Mazandaran province and Review on its current situation in Iran.  J Babol Univ Med Sci. 2011;13(2):68-75. (In Persian).
  12. Oryan A, Akbari M. Worldwide risk factors in leishmaniasis. Asian Pac J Trop Med. 2016;9(10):925-32. PMID: 27794384. https://doi.org/1016/j.apjtm.2016.06.021.
  13. Moradiasl E, Rassi Y, Hanafi-Bojd AA, Vatandoost H, Saghafipour A, Adham D, Aabasgolizadeh N, Omidi Oskouei A, Sadeghi H. The relationship between climatic factors and the prevalence of visceral leishmaniasis in North West of Iran. Int J Pediatr. 2018;6(2):7169-78.
  14. Sarkari B, Naraki T, Ghatee MA, Abdolahi Khabisi S, Davami MH. Visceral Leishmaniasis in Southwestern Iran: a retrospective clinico-hematological analysis of 380 consecutive hospitalized cases (1999–2014). PloS One. 2016;11(3):e0150406. https://doi.org/1371/journal.pone.0150406.
  15. Alavi-Naini R, Fazaeli A, O’dempsey T. Topical treatment modalities for old world cutaneous leishmaniasis: a review. Prague Med Rep. 2012;113(2):105-18. https://doi.org/14712/23362936.2015.26.
  16. Georgiadou SP, Makaritsis KP, Dalekos GN. Leishmaniasis revisited: current aspects on epidemiology, diagnosis and treatment. J Transl Int Med. 2015;3(2):43-50. https://doi.org/1515/jtim-2015-0002.
  17. Mcgwire BS, Satoskar A. Leishmaniasis: clinical syndromes and treatment. QJM: Int J Med. 2014;107(1):7-14. https://doi.org/1093/qjmed/hct116.
  18. Werneck GL. Visceral Leishmaniasis in Brazil: rationale and concerns related to reservoir control. Rev Saude Publica. 2014;48:851-6. PMID: 25372177. https://doi.org/1590/s0034-8910.2014048005615.
  19. Romero GA, Boelaert M. Control of Visceral leishmaniasis in Latin America-a systematic review. PLoS Negl Trop Dis. 2010;4(1):e584. PMID: 20098726. https://doi.org/1371/journal.pntd.0000584.
  20. González C, Wang O, Strutz SE, González-Salazar C, Sánchez-Cordero V, Sarkar S. Climate change and risk of leishmaniasis in North America: predictions from ecological niche models of vector and reservoir species. PLoS Negl Trop Dis. 2014;4(1):e585. https://doi.org/10.1371/journal.pntd.0000585.
  21. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. System Rev. 2015;4(1):1. https://doi.org/10.1186/2046-4053-4-1.
  22. Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. Int J Surg. 2014;12(12):1495-9. https://doi.org/1016/j.jclinepi.2007.11.008.
  23. Bazyar J, Safarpour H, Daliri S, Karimi A, Keykaleh MS, Bazyar M. The prevalence of sexual violence during pregnancy in Iran and the world: a systematic review and meta-analysis. J Inj Violence Res. 2018;10(2):63-74. https://doi.org/10.5249/jivr.v10i2.954.
  24. Sabzevari S, Mohebali M, Hashemi A. Cutaneous and visceral leishmaniasis: parasites, vectors and reservoir hosts in endemic foci of North Khorasan, Northeastern Iran-a Narrative Review. J Med Microbiol Infect Dis. 2020 Apr 10;8(2):40-4.
  25. Mohebali M, Moradi-Asl E, Rassi Y. Geographic distribution and spatial analysis of Leishmania infantum infection in domestic and wild animal reservoir hosts of zoonotic visceral leishmaniasis in Iran: A systematic review. Journal of vector borne diseases. 2018 Jul 1;55(3):173.
  26. Shokri A, Fakhar M, Teshnizi SH. Canine visceral leishmaniasis in Iran: A systematic review and meta-analysis. Acta tropica. 2017 Jan 1;165:76-89.
  27. Mohebali M, Hamzavi Y, Edrissian GH, Forouzani A. Seroepidemiological study of
    Visceral Leishmaniasis among humans and animal reservoirs in Bushehr province,
    Islamic Republic of Iran. East Mediter Health J. 2001;7(6):912-917. 238. PMID: 15332732
  28. Oryan A, Shirian S, Tabandeh MR, Hatam GR, Kalantari M, Daneshbod Y. Molecular, cytological, and immunocytochemical study and kDNA sequencing of laryngeal Leishmania infantum infection. Parasitol Rres. 2013;112(4):1799-804.
  29. Gavgani ASM, Mohite H, Edrissian GH, Mohebali M, Davies CR. Domestic dog ownership in Iran is a risk factor for human infection with Leishmania infantum. Am J Ttrop Med Hygiene.2002;67(5):511-5.https://doi.org/10.4269/ajtmh.2002.67.511.
  30. Hatam GR, Adnani SJ, Asgari Q, Fallah E, Motazedian MH, Sadjjadi SM, Sarkari B. First report of natural infection in cats with Leishmania infantum in Iran. Vector BorneZoonotic Dis. 2010;10(3):313-6. https://doi.org/10.1089/vbz.2009.0023.
  31. Fallah E, Farshchian M, Mazlomi A, Madjidi J, Kousha A, Mardi A, et al. Study on the prevalence of Visceral Leishmaniasis in rodent’s of Azarshahr district (new focus), northwest of Iran. Arc Razi Inst. 2006;61(1):33-40. https://doi.org/22092/ARI.2006.103724.
  32. Fakhar M, Motazedian MH, Asgari Q, Kalantari M. Asymptomatic domestic dogs are carriers of Leishmania infantum: possible reservoirs host for human Visceral Leishmaniasis in southern Iran. Comp Clin Path. 2012;21(5):801-7. https://doi.org/10.1007/s00580-011-1179-6.
  33. Akhtardanesh B, Sharifi I, Mohammadi A, Mostafavi M, Hakimmipour M, Pourafshar NG. Feline Visceral Leishmaniasis in Kerman, southeast of Iran: Serological and molecular study. J Vector Borne Dis. 2017;54(1):96.
  34. Rassi Y, Azizi K, Motazedian M, Javadian E, Rafizadeh S, Fakhar M, et al. The seminested PCR based detection of Leishmania infantum infection in asymptomatic dogs in a new endemic focus of Visceral Leishmaniasis in Iran. J Arthropod Borne Dis. 2007;38-42.
  35. Fakhar M, Motazedian M, Hatam G, Asgari Q, Kalantari M, Mohebali M. Asymptomatic human carriers of Leishmania infantum: possible reservoirs for Mediterranean Visceral Leishmaniasis in southern Iran. Ann Trop Med Parasitol. 2008;102(7):577-83. https://doi.org/10.1179/136485908X337526.
  36. Hajjaran H, Mohebali M, Mamishi S, Vasigheh F, Oshaghi MA, Naddaf SR, et al. Molecular identification and polymorphism determination of cutaneous and Visceral Leishmaniasis agents isolated from human and animal hosts in Iran. BioMed Res Int. 2013; https://doi.org/10.1155/2013/789326.
  37. Hajjaran H, Mohebali M, Teimouri A, Oshaghi MA, Mirjalali H, Kazemi-Rad E, et al. Identification and phylogenetic relationship of Iranian strains of various Leishmania species isolated from cutaneous and visceral cases of leishmaniasis based on N-acetylglucosamine-1-phosphate transferase gene. Infect Gen Evol. 2014;26:203-12. https://doi.org/10.1016/j.meegid.2014.05.026. Epub 2014 Jun 7.
  38. Bamorovat M, Sharifi I, Dabiri S, Mohammadi MA, Harandi MF, Mohebali M, et al. Leishmania tropica in stray dogs in southeast Iran. Iranian J Public Health. 2015;44(10):1359. PMCID: PMC4644581. PMID: 26576349.
  39. Mohebali M, Edrisian GH, Nadim A, Hajaran H, Akhoundi B, Houshmand B, Zareei Z, Arshi S, Mirsamadi N, Manouchehri NK, Mamishi S. Application of direct agglutination test (DAT) for the diagnosis and seroepidemiological studies of visceral leishmaniasis in Iran.. Iran J Parasitol. 2006;1(1):15-25.
  40. Rassi Y, Kaverizadeh F, Javadian E, Mohebali M. First report on natural promastigote infection of Phlebotomus caucasicus in a new focus of Visceral Leishmaniasis in North West of Iran. Iranian J Public Health. 2004;33(4):70-72.
  41. Parvizi P, Alaeenovin E, Mohammadi S, Baghban N. Occurrence of low density of Leishmania infantum in sandflies from a new focus of Visceral Leishmaniasis in northwest of Iran. J Vector Borne Dis. 2013;50(2):127. PMID: 23995314.
  42. Emami MM, Yazdi M. Entomological survey of phlebotomine sand flies (Diptera: Psychodidae) in a focus of Visceral Leishmaniasis in central Iran. J Vector Borne Dis. 2008;45(1):38. PMID: 18399315.
  43. Oshaghi MA, Ravasan NM, Hide M, Javadian E-A, Rassi Y, Sadraei J, et al. Phlebotomus perfiliewi transcaucasicus is circulating both Leishmania donovani and infantum in northwest Iran. Exp Parasitol. 2009;123(3):218-25. https://doi.org/10.1016/j.exppara.2009.07.004.
  44. Azizi K, Rassi Y, Motazedian MH, Javadian E, Yaghoobi-Ershadi MR, Rafizadeh S, et al. Phlebotomus (Paraphlebotomus) alexandri, the probable vector of Visceral Leishmaniasis (kalaazar) in southern Iran. J Sch Public Health Inst Public Health Res. 2006;4(4):39-48. (In Persian)
  45. Farzinnia B, Hanafi BA. The sand fly fauna of an endemic focus of Visceral Leishmaniasis in Central Iran. Iranian J Arthropod-Borne Dis. 2007;1(2):48- 52.
  46. Bahrami A, Rassi Y, Maleki N, Oshaghi M, Akhavan A, Yagoobi-Ershadi M, et Leishmania infantum DNA detection in Phlebotomus tobbi in a new northern focus of Visceral Leishmaniasis in Iran. Asian Pac J Trop Dis. 2014;4(2):110-4. https://doi.org/10.1016/S2222-1808(14)60325-X.
  47. Parvizi P, AlaeeNovin E. Simultaneous detection of of three Leishmania species in Kaleybar, a Focus of visceral leishmaniasis in northwest of Iran.  J Ardabil Univ Med Sci (JAUMS). 2011;2(40):121-133.
  48. Moradi-Asl E, Rassi Y, Adham D, Hanafi-Bojd AA, Saghafipour A, Rafizadeh S. Spatial distribution of sand flies (Diptera: Psychodidae; Larroussius group), the vectors of Visceral Leishmaniasis in Northwest of Iran. Asian Pac J Trop Biomed. 2018;8(9):425. https://doi.org/10.4103/2221-1691.242290.
  49. Azizi K, Rassi Y, Javadian E, Motazedian M, Asgari Q, Yaghoobi-Ershadi M. First detection of Leishmania infantum in Phlebotomus (Larroussius) major (Diptera: Psychodidae) from Iran. J Med Entomol. 2008;45(4):726-31. https://doi.org/10.1603/0022-2585(2008)45[726:fdolii]2.0.co;2.
  50. Rassi Y, Dehkordi AS, Oshaghi MA, Abai MR, Mohtarami F, Enayati A, et al. First report on natural infection of the Phlebotomus tobbi by Leishmania infantum in northwestern Iran. Exp Parasitol. 2012;131(3):344-9.
  51. Rassi Y, Javadian E, Nadim A, Rafizadeh S, Zahraii A, Azizi K, et al. Phlebotomus perfiliewi transcaucasicus, a vector of Leishmania infantum in northwestern Iran. J Med Entomol. 2009;46(5):1094-8. https://doi.org/1603/033.046.0516.
  52. Rassi Y, Karimi H, Abai MR, Mohebali M, Bakhshi H, Oshaghi MA, Rafizadeh S, Bagherpoor Hagigi H, Hosseini A, Gholami M. First detection of Leishmania infantum DNA in wild caught Phlebotomus papatasi in endemic focus of cutaneous leishmaniasis, South of Iran. Asian Pac J Trop Biomed. 2013;3(10):825-9. https://doi.org/1016/S2221-1691(13)60163-X.
  53. Hanafi‐Bojd A, Rassi Y, Yaghoobi‐Ershadi M, Haghdoost A, Akhavan A, Charrahy Z, et al. Predicted distribution of Visceral Leishmaniasis vectors (Diptera: Psychodidae; Phlebotominae) in Iran: a niche model study. Zoonose Public Health. 2015;62(8):644-54. https://doi.org/1111/zph.12202.
  54. Nemati T, Khanmohammadi M, Bazmani A, Mirsamadi N, Koshki MH, Mohebali M, Fatollahzadeh M, Fallah E. Study on Leishmania infection in cats from Ahar, East Azerbaijan Province and North West Iran by parasitological, serological and molecular methods. Asian Pac J Trop Biomed. 2015;5(1):40-3.
  55. Mohebali M, Motazedian M, Parsa F, Hajjaran H, Yaghoobi-Ershadi M. Identification of Leishmania species from different parts of Iran using a random amplified polymorphic DNA in humans, animal reservoirs and vectors. Med J Islamic Rep Iran (MJIRI). 2002;15(4):243-6.
  56. Ansari H, Moshfe A, Solhjoo K, Khodadadi P, Kalantari M, Afshoon E, et al. Characterization of Visceral Leishmaniasis in reservoir host (dogs) and determination of agent by PCR in Boyer-Ahmad District, Iran. Armaghane Danesh. 2012;16(6):537-44. (In Persian)
  57. Mohebali M, Javadian E, Yaghoobi Ershadi M, Akhavan A, Hajjaran H, Abaei M. Characterization of Leishmania infection in rodents from endemic areas of the Islamic Republic of Iran. East Mediter Health J. 2004;10(4-5):591-599. PMID: 16335651.
  58. Khanmohammadi M, Fallah E, Rahbari S, Hesaraki S. Seroprevalence survey on wild canine visceral leishmaniasis in sarab district (east azerbaijan province) northwest of Iran during 2009-2010. J Vet Clin Path. 2011;4(16):997-1005.
  59. Mohebali M. Epidemiological status of Visceral Leishmaniasis in Iran: experiences and review of literature. J Clinic Exp Path. 2012;S3:1-5. https://doi.org/4172/2161-0681.S3-003.
  60. Salahi-Moghaddam A, Khoshdel A, Hanafi-Bojd A-A, Sedaghat M-M. Mapping and review of leishmaniasis, its vectors and main reservoirs in Iran. J Kerman Univ Med Sci. 2015;22(1):83-104. (In Persian).
  61. Mohebali M, Moradi-Asl E, Rassi Y. Geographic distribution and spatial analysis of Leishmania infantum infection in domestic and wild animal reservoir hosts of zoonotic Visceral Leishmaniasis in Iran: A systematic review. J Vector Borne Dis. 2018;55(3):173. https://doi.org/4103/0972-9062.249125.
  62. Shokri A, Fakhar M, Teshnizi SH. Canine Visceral Leishmaniasis in Iran: A systematic review and meta-analysis. Acta trop. 2017;165:76-89. https://doi.org/1016/j.actatropica.2016.08.020.
  63. Alemayehu B, Alemayehu M. Leishmaniasis: a review on parasite, vector and reservoir host. Health Sc J. 2017;11(4):1. https://doi.org/21767/1791-809X.1000519.
  64. Azizi K, Davari B, Kalantari M, Fekri S. Gerbillid rodents fauna (Muridae: Gerbillinae) and detection of reservoir hosts (s) of zoonotic cutaneous leishmaniasis using a nested-PCR technique in Jask City in Hormozgan Province in 2008. Sci. J Kurdistan Univ Med Sci. 2011;16(2).
  65. Azizi K, Badzohreh A, Sarkari B, Fakoorziba MR, Kalantari M, Moemenbellah-Fard MD, Ali-Akbarpour M. Nested polymerase chain reaction and sequence-based detection of Leishmania infection of sand flies in recently emerged endemic focus of zoonotic cutaneous leishmaniasis, southern Iran. Iranian J Med Sci. 2013;38(2 Suppl):156.
  66. Moemenbellah-Fard MD, Ahmadyousefi-Sarhadi M, Azizi K, Fakoorziba MR, Kalantari M, Amin M. Faunal identification and frequency distribution of wild sand flies infected with Leishmania tropica. Asian Pac J Trop Dis. 2015;5(10):792-7.
  67. Pourmohammadi B, Mohammadi-Azni S, Kalantari M. Natural infection of Nesokia indica with Leishmania major and Leishmania infantum parasites in Damghan city, Northern Iran. Acta trop. 2017;170:134-9.
  68. Mohebali M, Moradi-Asl E, Rassi Y. Geographic distribution and spatial analysis of Leishmania infantum infection in domestic and wild animal reservoir hosts of zoonotic visceral leishmaniasis in Iran: A systematic review. J Vector Borne Dis. 2018;55(3):173.

 

Journal of Health Sciences & Surveillance System
Volume 10, Issue 3
July 2022
Pages 257-265
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