Document Type : Original Article


1 Department of General Surgery, School of Medicine, Isfahan University of Medical Sciences, Iran

2 Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Iran

3 School of Medicine, Isfahan University of Medical Sciences, Iran

4 Department of Operation Room Technology, Ayatollah Kashani Hospital, Isfahan University of Medical Sciences, Iran


Background: Hand dermatitis is a group of diseases that result in inflammation of the skin in the area of the hand. The prevalence of latex allergies has been increasing in recent years, one of the reasons being the use of latex gloves to maintain safety. This study aimed to evaluate the effect of wearing cotton-polyester gloves under surgical latex gloves to improve the symptoms. Methods: This study is a randomized controlled clinical trial performed in Alzahra and Ayatollah Kashani hospitals in Isfahan. The statistical population consisted of the staff of the surgery room. Sampling was done by the census from October 2018 to March 2019. Cotton-polyester gloves (weight between 5–10 grams, 50% cotton and 50% polyester) are soft and flexible and easily absorb the sweat- under latex gloves. Also, it can be re-sterilized with ethylene oxide. In rupture of surgical gloves due to strong and integrated stitching, the cotton-polyester gloves prevent hand burns with electrocautery or damage by sharp objects. These gloves were distributed and used among the samples for 6 months. Results: Data were analyzed based on symptoms of erythema, appearance, economic burden, and disruption in daily life; there was a significant relationship between lack of using cottonpolyester gloves under the surgical gloves compared to when using them (P<0.01). However, there was no significant relationship between pain and disorder in social relations (P>0.01). Conclusion: Using cotton-polyester gloves under surgical latex gloves can improve the symptoms of dermatitis. On the other hand, the use of these gloves will not interfere with the function of the hands.


  1. Bains SN, Fonacier L. Irritant contact dermatitis.Clinical reviews in allergy & immunology. 2019 Feb15;56(1):99-109.
  2. Kelly KJ, Sussman G. Latex allergy: where are wenow and how did we get there?. The Journal of Allergyand Clinical Immunology: In Practice. 2017 Sep1;5(5):1212-6.
  3. Wollenberg A, Christen‐Zäch S, Taieb A, Paul C,Thyssen JP, de Bruin‐Weller M, Vestergaard C,Seneschal J, Werfel T, Cork MJ, Kunz B. ETFAD/EADVEczema task force 2020 position paper on diagnosis andtreatment of atopic dermatitis in adults and children.Journal of the European Academy of Dermatology and 2020 Dec;34(12):2717-44.
  4. Darvishi E, Golestan S, Demehri F, Jamalnia S. Across-sectional study on cognitive errors and obsessivecompulsive disorders among young people duringthe outbreak of coronavirus disease 2019. ActivitasNervosa Superior. 2020 Dec;62(4):137-42.
  5. Liberatore K, Kelly KJ. Latex allergy risks live on.The Journal of Allergy and Clinical Immunology: In 2018 Nov 1;6(6):1877-8.
  6. Bedolla-Barajas M, de la Luz Machuca-RincónM, Morales-Romero J, Macriz-Romero N, MaríaMadrigal Beas I, Robles-Figueroa M, Bedolla-PulidoTR, González-Mendoza T. Self-reported prevalenceof latex allergy and associated factors in healthcare Revista Alergia de Mexico. 2017 Oct 1;64(4).
  7. DeGuzman RD, Vedanthan PK. Latex Allergy.InTextbook of Allergy for the Clinician 2021 Feb 4(pp. 403-409). CRC Press.
  8. Nguyen HL, Yiannias JA. Contact dermatitis tomedications and skin products. Clinical reviews inallergy & immunology. 2019 Feb 15;56(1):41-59.
  9. Cao LY, Taylor JS, Sood A, Murray D, Siegel PD.Allergic contact dermatitis to synthetic rubber gloves:changing trends in patch test reactions to accelerators.Archives of dermatology. 2010 Sep 1;146(9):1001-7.
  10. Vandenplas O, Raulf M. Occupational latex allergy:the current state of affairs. Current allergy and asthma 2017 Mar 1;17(3):14.
  11. Raulf M, Rihs HP. Latex allergens: source ofsensitization and single allergens. InMolecular allergydiagnostics 2017 (pp. 459-470). Springer, Cham.
  12. Jaeger D, Kleinhans D, Czuppon AB, Baur X. Latexspecific proteins causing immediate-type cutaneous,nasal, bronchial, and systemic reactions. Journalof allergy and clinical immunology. 1992 Mar1;89(3):759-68.
  13. Charous BL, Hamilton RG, Yunginger JW. Occupationallatex exposure: characteristics of contact and systemicreactions in 47 workers. Journal of Allergy and Clinical 1994 Jul 1;94(1):12-8.
  14. Vandenplas O, Larbanois A, Vanassche F, François S,Jamart J, Vandeweerdt M, Thimpont J. Latexinducedoccupational asthma: time trend in incidence andrelationship with hospital glove policies. Allergy. 2009Mar;64(3):415-20.
  15. Liu Q-L, He X-Z, Liang K, Xie R, Fang H-P, ZhuK-J, et al. Prevalence and risk factors for latex gloveallergy among female clinical nurses: a multicenterquestionnaire study in China. Int J Occup Environ 2010 Mar 1;15(1):25–00.
  16. Wright HT, Brooks DM, Wright CS. Evolution of themultidomain protein wheat germ agglutinin. Journalof molecular evolution. 1985 Feb;21(2):133-8.
  17. Nedorost ST. Generalized dermatitis in clinical Springer Science & Business Media; 2012Jul 6.
  18. Favilla J, Marcicano JP, Sanches RA, Maia MO.Non-occlusive knitted linen for atopic dermatitis International Journal of Clothing Science andTechnology. 2017 Jun 5.