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Quercetin and Male Fertility: A Literature Review

Document Type : Review Articles

Authors

1 School of Medicine, Mashhad Azad University, Mashhad, Iran

2 School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department Gynecology Nncology, Kamali Teaching Hospital, Alborz University of Medical Sciences, Karaj, Iran

4 Fasa University of Medical Sciences, Fasa, Iran

5 School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Infertility causes social and psychological distress and has negative economic effects on healthcare systems. Infertility is the incapability to conceive after at least 12 months of unprotected regular sexual intercourse. Finding the impacts of herbal antioxidants can result in new visions for enhancing male fertility. Quercetin belongs to the bioflavonoids family, and many nutritionists, scientists, and researchers have investigated its pharmacokinetic and pharmacodynamic properties in their studies.
Methods: In this review, the authors summarized the protecting role of quercetin against oxidative damage and toxic metals stimulating male infertility by searching in PubMed, Web of Science, Scopus, and Embase via the keywords “male infertility”, “quercetin”, “male fertility”, “oxidative stress”, “toxic metals”, “environmental contaminants”, and “heavy metals” without language or date restrictions.
Results: Due to insufficient antioxidant defenses and inadequate cell repair systems, spermatozoa are predominantly susceptible to oxidative stress and toxic agents, especially heavy metals. Reactive oxygen species mediate several other cellular mechanisms, such as apoptosis. Previous research has highlighted quercetin and polyphenols’ positive and negative impact on male fertility.
Conclusion: Quercetin exerts its beneficial functions through its antioxidant capacity by scavenging ROS and chelating toxic heavy metals and other environmental contaminants; thus, it can prevent male infertility.

Highlights

Sahar Poudineh (Google Scholar)

Keywords

References
  1. Szentmihályi K, Szőllősi-Varga I, Then M. ELEMENTS, ALKALOIDS AND ANTIOXIDANT VALUE OF CHELIDONIUM MAJUS L. AND THE EXTRACTS OBTAINED BY DIFFERENT EXTRACTION METHODS. EUROPEAN CHEMICAL BULLETIN. 2021;10(1):58-66. doi: 10.17628/ecb.2021.10.58-66.
  2. Qahir A, Khan N, Hakeem A, Kamal R. The antioxidant, antimicrobial, and clinical effects with elemental contents of pomegranate (Punica granatum) peel extracts: A review. Baghdad Journal of Biochemistry and Applied Biological Sciences. 2021;2(01):21-8. doi: 10.47419/bjbabs.v2i01.33.
  3. Irondi EA. Phenolics-rich extract of guava stem bark inhibits enzymes associated with nephrolithiasis and obesity in vitro. Journal of Complementary Medicine Research. 2020;11(1):34-42.
  4. Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. Journal of nutritional science. 2016; 5: e47. doi: 10.1017/jns.2016.41.
  5. Karak P. Biological activities of flavonoids: an overview. International Journal of Pharmaceutical Sciences and Research. 2019;10(4):1567-74.
  6. Datkhile KD, Patil SR, Durgawale P, Patil M, Jagdale NJ, Deshmukh VN. Studies on phytoconstituents, in vitro antioxidant, antibacterial and cytotoxicity potential of Argemone mexicana Linn. (family: Papaveraceae). J Nat Sci Biol Med. 2020; 11:198-205.
  7. Palungwachira P, Tancharoen S, Dararat P, Nararatwanchai T. Anthocyanins isolated from Oryza Sativa L. protect dermal fibroblasts from hydrogen peroxide-induced cell death. Journal of Natural Science, Biology and Medicine. 2020;11(1):45-54.
  8. Nizer WSDC, Ferraz AC, Moraes TDFS, Ferreira FL, Vieira-Filho SA, Duarte LP. Lack of activity of rutin isolated from Tontelea micrantha leaves against Vero and BHK, fungi, bacteria and Mayaro virus and it is in silico activity. Journal of Pharmaceutical Negative Results. 2020;11(1):9-.
  9. Wright C, Milne S, Leeson H. Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility. Reproductive biomedicine online. 2014;28(6): 684-703. doi: 10.1016/j.rbmo.2014.02.004.
  10. Ly C, Yockell-Lelievre J, Ferraro ZM, Arnason JT, Ferrier J, Gruslin A. The effects of dietary polyphenols on reproductive health and early development. Human reproduction update. 2015;21(2):228-48. doi: 10.1093/humupd/dmu058.
  11. Moretti E, Mazzi L, Bonechi C, Salvatici MC, Iacoponi F, Rossi C, et al. Effect of Quercetin-loaded liposomes on induced oxidative stress in human spermatozoa. Reproductive Toxicology. 2016; 60:140-7. doi: 10.1016/j.reprotox.2016.02.012.
  12. Vakili S, Zal F, Mostafavi‐pour Z, Savardashtaki A, Koohpeyma F. Quercetin and vitamin E alleviate ovariectomy‐induced osteoporosis by modulating autophagy and apoptosis in rat bone cells. Journal of Cellular Physiology. 2021;236(5):3495-509. doi: 10.1002/jcp.30087.
  13. Paul R, Mukkadan J. Modulation of blood glucose, oxidative stress, and anxiety level by controlled vestibular stimulation in prediabetes. J Nat Sci Biol Med. 2020; 11:111-7.
  14. Chulovska Z, Drapak I, Chaban T, Ogurtsov V, Chaban I, Matiychuk V. Synthesis, anticancer and antioxidant properties of some 4-thioxo-thiazolidin-2-ones. European Chemical Bulletin. 2021;10(3):147-54.
  15. Pal N, Joshi M. Piper nigrum: An overview of effects on human health. International Journal of Pharmacy Research & Technology. 2021;11(1):25-32.
  16. Agarwal A, Rana M, Qiu E, AlBunni H, Bui AD, Henkel R. Role of oxidative stress, infection and inflammation in male infertility. Andrologia. 2018;50(11): e13126. doi: 10.1111/and.13126.
  17. Nishimura H, L’Hernault SW. Spermatogenesis. Current Biology. 2017;27(18): R988-R94. doi: 10.1016/j.cub.2017.07.067.
  18. Saeed B, Baban R, Al-Nasiri U. Lactate dehydrogenase C4 (LDH-C4) is essential for the sperm count and motility: A case-control study. Baghdad Journal of Biochemistry and Applied Biological Sciences. 2021;2(03):146-59.
  19. Chu DS, Shakes DC. Spermatogenesis. Germ cell development in C elegans. 2013; 757:171-203. doi: 10.1007/978-1-4614-4015-4_7.
  20. Holdcraft RW, Braun RE. Hormonal regulation of spermatogenesis. International journal of andrology. 2004;27(6):335-42. doi: 10.1111/j.1365-2605.
  21. Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clinical biochemistry. 2018; 62:2-10. doi: 10.1016/j.clinbiochem.2018.03.012.
  22. Wu AK, Elliott P, Katz PP, Smith JF. Time costs of fertility care: the hidden hardship of building a family. Fertility and sterility. 2013;99(7):2025-30. doi: 10.1016/j.fertnstert.2013.01.145.
  23. Krausz C. Male infertility: pathogenesis and clinical diagnosis. Best practice & research Clinical endocrinology & metabolism. 2011;25(2):271-85. doi: 10.1016/j.beem.2010.08.006.
  24. Ali A-R, Abdul-Rasheed O, Alkawaz U. Follicle-stimulating hormone (FSH) receptor gene polymorphisms in Iraqi patients with non-obstructive azoospermia. Baghdad Journal of Biochemistry and Applied Biological Sciences. 2021;2(04):187-202.
  25. Sabanegh ES, Agarwal A. Male infertility: Springer; 2011.
  26. Irvine DS. Epidemiology and aetiology of male infertility. Human reproduction. 1998;13(suppl_1):33-44. doi: 10.1093/humrep/13.suppl_1.33.
  27. Meacham RB, Joyce GF, Wise M, Kparker A, Niederberger C, Project UDiA. Male infertility. The Journal of urology. 2007;177(6):2058-66. doi: 10.1016/j.juro.2007.01.131.
  28. Taskan MM, Gevrek F. Quercetin decreased alveolar bone loss and apoptosis in experimentally induced periodontitis model in wistar rats. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents). 2020;19(4):436-48. doi: 10.2174/1871523019666200124114503.
  29. Jafari Khorchani M, Samare-Najaf M, Abbasi A, Vakili S, Zal F. Effects of quercetin, vitamin E, and estrogen on Metabolic-Related factors in uterus and serum of ovariectomized rat models. Gynecological Endocrinology. 2021;37(8):1-5. doi: 10.1080/09513590.2021.1879784.
  30. Kadhom M, Al-Doori AN, Ahmed DS, Yousif E. Herbal medicine as an alternative method to treat and prevent COVID-19. Baghdad Journal of Biochemistry and Applied Biological Sciences. 2021;2(01):1-20.
  31. Gupta A, Birhman K, Raheja I, Sharma SK, Kar HK. Quercetin: A wonder bioflavonoid with therapeutic potential in disease management. Asian Pacific Journal of Tropical Disease. 2016;6(3):248-52.
  32. Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, et al. Encyclopedia of dietary supplements: CRC Press; 2010.
  33. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. European journal of pharmacology. 2008;585(2-3):325-37. doi: 10.1016/j.ejphar.2008.03.008.
  34. Sakanashi Y, Oyama K, Matsui H, Oyama TB, Oyama TM, Nishimura Y, et al. Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: a model experiment. Life sciences. 2008;83(5-6):164-9. doi: 10.1016/j.lfs.2008.05.009.
  35. Young I, McEneny J. Lipoprotein oxidation and atherosclerosis. Portland Press Ltd.; 2001.
  36. Seddiki Y, da Silva FM, da Silva FM. Antioxidant properties of polyphenols and their potential use in improvement of male fertility: a review. Biomed J Sci Tech Res. 2017;1(3):612-7.
  37. Ranawat P, Pathak CM, Khanduja KL. A new perspective on the quercetin paradox in male reproductive dysfunction. Phytotherapy Research. 2013;27(6):802-10. doi: 10.1002/ptr.4799.
  38. Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: A systematic review on evaluation and management. Arab journal of urology. 2019;17(2):87-97. doi: 10.1080/2090598X.2019.1599624.
  39. Jasirwan S, Iffanolida P, Santawi VA, Friska D, Wiweko B. Relationship between morphology of tripronuclear embryo and chromosomal abnormalities potential in intracytoplasmic sperm injection cycles. Journal of Natural Science, Biology and Medicine. 2019;10(3):92-8.
  40. Agarwal A, Sharma RK, Nallella KP, Thomas Jr AJ, Alvarez JG, Sikka SC. Reactive oxygen species as an independent marker of male factor infertility. Fertility and sterility. 2006;86(4):878-85.
  41. Gomes IBS, Porto ML, Santos MCLFS, Campagnaro BP, Gava AL, Meyrelles SS, et al. The protective effects of oral low-dose quercetin on diabetic nephropathy in hypercholesterolemic mice. Frontiers in physiology. 2015; 6:247. doi: 10.3389/fphys.2015.00247.
  42. Banday MN, Lone FA, Rasool F, Rashid M, Shikari A. Use of antioxidants reduce lipid peroxidation and improve quality of crossbred ram sperm during its cryopreservation. Cryobiology. 2017; 74:25-30. doi: 10.1016/j.cryobiol.2016.12.008.
  43. Zribi N, Chakroun NF, Abdallah FB, Elleuch H, Sellami A, Gargouri J, et al. Effect of freezing–thawing process and quercetin on human sperm survival and DNA integrity. Cryobiology. 2012;65(3):326-31. doi: 10.1016/j.cryobiol.2012.09.003.
  44. Li G, Ma A, Shi W, Zhong X. Quercetin protects hamster spermatogenic cells from oxidative damage induced by diethylstilboestrol. Andrologia. 2010;42(5):285-90. doi: 10.1111/j.1439-0272.2009.00990.x.
  45. Ma A, Yang X, Wang Z, Shi D, Chen Y. Adult exposure to diethylstilbestrol induces spermatogenic cell apoptosis in vivo through increased oxidative stress in male hamster. Reproductive Toxicology. 2008;25(3):367-73.
  46. Hosseinabadi F, Faraji T, Malmir M. Impact of Quercetin on Sperm parameters, Testicular Tissue, and Sex Hormone: A Systematic Review. Jorjani Biomedicine Journal. 2021; 9(4):33-54.
  47. Alaee S. Air pollution and infertility–a letter to editor. J of Environ Treat Tech. 2018;6(4):72-3.
  48. Mansoor A, Roghaye D. Adsorptive performance of Iminodiacetic acid functionalized nanoporous carbon for removal of Pb (II), Cu (II) and Cd (II) ions in aqueous system. Journal of Environmental Treatment Techniques. 2018;6(2):26-32.
  49. Azadi S, Karimi-Jashni A, Talebbeydokhti N, Khoshbakht R, Haghighi AB. Industrial composting of commingled municipal solid waste: A case study of Shiraz City, Iran. Journal of Environmental Treatment Techniques. 2020;8(4):1292-303.
  50. Mathur N, Pandey G, Jain G. Male reproductive toxicity of some selected metals: A review. Journal of biological sciences. 2010;10(5):396-404.
  51. Ravichandran R, Rajendran M, Devapiriam D. Structural characterization and physicochemical properties of quercetin–Pb complex. Journal of Coordination Chemistry. 2014;67(8):1449-62.
  52. Jahan S, Iftikhar N, Ullah H, Rukh G, Hussain I. Alleviative effect of quercetin on rat testis against arsenic: a histological and biochemical study. Systems Biology in Reproductive Medicine. 2015;61(2):89-95. doi: 10.3109/19396368.2014.998350.
  53. Al-Omair MA, Sedky A, Ali A, Elsawy H. Ameliorative potentials of quercetin against lead-induced hematological and testicular alterations in Albino rats. Chin J Physiol. 2017;60(1):54-61. doi: 10.4077/CJP.2017.BAF440.
  54. Mao T, Han C, Wei B, Zhao L, Zhang Q, Deng R, et al. Protective effects of quercetin against cadmium chloride-induced oxidative injury in goat sperm and zygotes. Biological trace element research. 2018;185(2):344-55. doi: 10.1007/s12011-018-1255-8.
  55. Farombi E, Adedara I, Akinrinde S, Ojo O, Eboh A. Protective effects of kolaviron and quercetin on cadmium‐induced testicular damage and endocrine pathology in rats. Andrologia. 2012;44(4):273-84. doi: 10.1111/j.1439-0272.2012.01279.x.
  56. Ciftci O, Aydin M, Ozdemir I, Vardi N. Quercetin prevents 2, 3, 7, 8‐tetrachlorodibenzo‐p‐dioxin‐induced testicular damage in rats. Andrologia. 2012;44(3):164-73. doi: 10.1111/j.14390272.2010.01126.x.
  57. Ujah G, Nna V, Agah M, Omue L, Leku C, Osim E. Effect of quercetin on cadmium chloride‐induced impairments in sexual behaviour and steroidogenesis in male Wistar rats. Andrologia. 2018;50(2):e12866. doi: 10.1111/and.12866.
  58. Zhang YMC. Protective effect of quercetin on Aroclor 1254–induced oxidative damage in cultured chicken spermatogonial cells. Toxicological Sciences. 2005;88(2):545-50. doi: 10.1093/toxsci/kfi333.
  59. Mi Y, Zhang C, Li C, Taneda S, Watanabe G, Suzuki AK, et al. Quercetin protects embryonic chicken spermatogonial cells from oxidative damage intoxicated with 3-methyl-4-nitrophenol in primary culture. Toxicology letters. 2009;190(1):61-5. doi: 10.1016/j.toxlet.2009.07.002.
  60. Mi Y, Zhang C, Li C, Taneda S, Watanabe G, Suzuki AK, et al. Protective effect of quercetin on the reproductive toxicity of 4-nitrophenol in diesel exhaust particles on male embryonic chickens. Journal of Reproduction and Development. 2010;56(2):0912210235-. doi: 10.1262/jrd.09-074n.
  61. Mi Y, Zhang C, Taya K. Quercetin protects spermatogonial cells from 2, 4-d-induced oxidative damage in embryonic chickens. Journal of Reproduction and Development. 2007;53(4):0703260066. doi: 10.1262/jrd.19001.
  62. Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch‐Ernst KI, et al. Safety aspects of the use of quercetin as a dietary supplement. Molecular Nutrition & Food Research. 2018;62(1):1700447.
Journal of Health Sciences & Surveillance System
Volume 11, Issue 4
October 2023
Pages 679-685
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