Document Type : Original Articles

Authors

1 Candidate of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran

2 Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran

4 Non-communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background:
Insulin-dependent diabetes mellitus (IDDM) or type 1 diabetes mellitus (T1DM) is known as a chronic autoimmune disease with an increasing prevalence and incidence. This study was conducted to determine the incidence rate and prevalence of insulin-dependent diabetes in Iran in 2016 and 2017.
 
Methods:
In this cross-sectional study, the prevalence of IDDM in insured subjects under the age of 19 was measured through the prescribed insulin in two consecutive years. In this study, we assumed that IDDM patients are those who receive at least one prescription containing any insulin over 2 years in insurance databases. This study was   carried out on 98% of patients under age 19, and the prevalence and incidence of IDDM were calculated. Finally, the result of this method was compared with Integrated Health System (IHS) databases.
Results:
In general, 1,135,105 insured persons under 19 years of age were enrolled in this study, and the prevalence rates of IDDM in subjects under 19 were 117.6 (111.5-124.2) and 136.8 (130.1-143.8) per 100,000 in 2016 and 2017, respectively. The incidence rate of this disease was 27.4 (24.6-30.8) per 100,000. The highest incidence and prevalence were significantly observed in the age group of 14-19 years. The prevalence of IDDM was not significantly different between boys and girls.
Conclusion:
The results of this study showed that the method of prescription follow up was appropriate, acceptable, convenient, and accurate. Our findings showed that the incidence and prevalence of IDDM in this method were in line with other worldwide reliable and accurate reports, even in the developed countries. The results of the present study showed that the prevalence and incidence rate of IDDM in Iran (Fars province) is at an intermediate level.

Keywords

1.            Association AD. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37(Supplement 1):S81-S90.
2.            Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives. Nature reviews endocrinology. 2012;8(4):228.
3.            Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes research and clinical practice. 2014;103(2):137-49.
4.            Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes research and clinical practice. 2011;94(3):311-21.
5.            Association AD. 2. Classification and diagnosis of diabetes. Diabetes care. 2015;38(Supplement 1):S8-S16.
6.            Razavi Z, Karimpourian A, Moradi Aramian L, Bazmamoun H. Demographic characteristics of type 1 diabetic children and adolescents in Hamadan, Iran. Journal of research in health sciences. 2015;15(3):196-9.
7.            Group DP. Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999. Diabetic Medicine. 2006;23(8):857-66.
8.            Tuomilehto J. The emerging global epidemic of type 1 diabetes. Current diabetes reports. 2013;13(6):795-804.
9.            Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G, Group ES. Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. The Lancet. 2009;373(9680):2027-33.
10.          Green A, Gale E, Patterson C. Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE Study. The Lancet. 1992;339(8798):905-9.
11.          Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes care. 2000;23(10):1516-26.
12.          Dabelea D, Bell RA, D'Agostino JR, Imperatore G, Johansen JM, Linder B, et al. Incidence of diabetes in youth in the United States. Jama. 2007;297(24):2716-24.
13.          Pishdad GR. Low incidence of type 1 diabetes in Iran. Diabetes care. 2005;28(4):927-8.
14.          Xu Y, Liu G, Zhou Y, Lu Z, Shi Z, Wang J. The genetic association between LMP2 and LMP7 polymorphisms and susceptibility of insulin dependent diabetes mellitus: A meta-analysis. Medicine. 2020;99(13):e19482.
15.          Liese A, D'Agostino Jr R, Hamman R, Kilgo P, Lawrence J, Liu L, et al. SEARCH for Diabetes in Youth Study Group. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Diabetes Care. 2007;30(1):197-9.
16.          Sartor F, Walckiers D. Estimate of disease prevalence using drug consumption data. American journal of epidemiology. 1995;141(8):782-7.
17.          Linehan C, Kerr MP, Walsh PN, Brady G, Kelleher C, Delanty N, et al. Examining the prevalence of epilepsy and delivery of epilepsy care in Ireland. Epilepsia. 2010;51(5):845-52.
18.          Bargagli AM, Colais P, Agabiti N, Mayer F, Buttari F, Centonze D, et al. Prevalence of multiple sclerosis in the Lazio region, Italy: use of an algorithm based on health information systems. Journal of neurology. 2016;263(4):751-9.
19.          Liatis S, Dafoulas GE, Kani C, Politi A, Litsa P, Sfikakis PP, et al. The prevalence and treatment patterns of diabetes in the Greek population based on real-world data from the nation-wide prescription database. diabetes research and clinical practice. 2016;118:162-7.
20.          Rosenbloom AL, Joe JR, Young RS, Winter WE. Emerging epidemic of type 2 diabetes in youth. Diabetes care. 1999;22(2):345-54.
21.          H S. Geographical analysis of fertility status in Khorasan Razavi province. Human Geography Research. 2010;70:65-76.
22.          Ali nezhad Z AM. Fertility differences in Hormozgan province in 1996. 1997.
23.          Toodeh Falah M KpS. A STUDY ON THE EFFECT OF MODERNIZATION ON MARRIAGE AGE WITH EMPHASIS ON DEMOGRAPHIC INDICES OF MARRIAGE EVENT IN WHOLE COUNTRY AND 7 SELECTED PROVINCES IN 2006. 3. 2010;8:105-30.
24.          H M. Age of marriage rising: reviewing the supporting factors. Sociological Review. 2004;24(24):27-53.
25.          Tabatabaei A, Fallah Z, Haghighi S, Farmani M, Horri N, Eslamian Z, et al. Prevalence and Risk Factors for Gestational Diabetes Mellitus in Pregnant Women of Isfahan, Iran. Iranian Journal of Endocrinology and Metabolism. 2007;9(3):251-9.
26.          Hadaegh F KAM, Rahimi SH, Toohidi M. Prevalence of Gestational Diabetes in Pregnant Women in Bandar Abbas. 2004;6(3):225-33.
27.          Signorell A, Helsana Versicherungen A. A (ardworking Assistant for Describing Data. 2014.
28.          Zimmet P, Alberti KG, Magliano DJ, Bennett PH. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nature Reviews Endocrinology. 2016;12(10):616.
29.          Katsarou A, Gudbjörnsdottir S, Rawshani A, Dabelea D, Bonifacio E, Anderson BJ, et al. Type 1 diabetes mellitus. Nature reviews Disease primers. 2017;3:17016.
30.          Berhan Y, Waernbaum I, Lind T, Möllsten A, Dahlquist G, Group SCDS. Thirty years of prospective nationwide incidence of childhood type 1 diabetes: the accelerating increase by time tends to level off in Sweden. Diabetes. 2011;60(2):577-81.
31.          Gale EA. The rise of childhood type 1 diabetes in the 20th century. Diabetes. 2002;51(12):3353-61.
32.          Di Napoli A, Scalmana S, Franco F, Di Lallo D, Lacorte E, Vanacore N. Prevalence of parkinsonism estimated using the drug prescription archive: a possible method to estimate the prevalence of a chronic neurological disease? Journal of Neural Transmission. 2016;123(4):415-20.
33.          Lai B, Schulzer M, Marion S, Teschke K, Tsui J. The prevalence of Parkinson's disease in British Columbia, Canada, estimated by using drug tracer methodology. Parkinsonism & related disorders. 2003;9(4):233-8.
34.          Chini F, Pezzotti P, Orzella L, Borgia P, Guasticchi G. Can we use the pharmacy data to estimate the prevalence of chronic conditions? a comparison of multiple data sources. BMC Public Health. 2011;11(1):688.
35.          Liese AD, D'Agostino RB, Jr., Hamman RF, Kilgo PD, Lawrence JM, Liu LL, et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics. 2006;118(4):1510-8.
36.          Imperatore G, Mayer-Davis EJ, Orchard TJ, Zhong VW. Prevalence and incidence of type 1 diabetes among children and adults in the United States and comparison with non-US countries. Childhood. 2010;2006:0-19.
37.          Mayer-Davis EJ, Beyer J, Bell RA, Dabelea D, D'Agostino R, Jr., Imperatore G, et al. Diabetes in African American youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care. 2009;32 Suppl 2:S112-22.
38.          Sutton DL, Lyle DM, Pierce JP. Incidence and prevalence of insulin‐dependent diabetes mellitus in the zero‐to 19‐years' age‐group in Sydney. Medical Journal of Australia. 1989;151(3):140-6.
39.          Patterson C, Guariguata L, Dahlquist G, Soltész G, Ogle G, Silink M. Diabetes in the young–a global view and worldwide estimates of numbers of children with type 1 diabetes. Diabetes research and clinical practice. 2014;103(2):161-75.
40.          Writing Group for the SfDiYSG, Dabelea D, Bell RA, D'Agostino RB, Imperatore G, Johansen JM, et al. Incidence of diabetes in youth in the United States. JAMA. 2007;297(24):2716-24.
41.          Reunanen A, ÅKERBLOM HK, KÄÄR ML. Prevalence and ten‐year (1970‐1979) incidence of insulin‐dependent diabetes mellitus in children and adolescents in Finland. Acta Paediatrica. 1982;71(6):893-9.
42.          Soltesz G, Patterson C, Dahlquist G, Group ES. Worldwide childhood type 1 diabetes incidence–what can we learn from epidemiology? Pediatric diabetes. 2007;8:6-14.
43.          Health AIo, Welfare. Incidence of type 1 diabetes in Australia 2000–2013. 2015.