Document Type : Original Article

Authors

1 Faculty of Sciences and Technology, University of Ain Témouchent, Algeria

2 Institute of veterinary Science, University of Saad Dahlab Blida1 PB: 09000, Blida, Algeria

3 Agro-food Department, Faculty of Natural and Life Science, University of Saad Dahlab Blida1 PB: 09000, Blida, Algeria

10.30476/jhsss.2024.100428.1842

Abstract

Background: Brucellosis, as a zoonotic disease, is widespread among humans and animal andcontinues to be a major public health problem. The present study aimed to analyze the trends and epidemiological characteristics of human brucellosis in Ain Témouchent (Western Algeria).
Methods: In this registry-based longitudinal study, data on the reported new cases of brucellosis for five years (2014 to 2019) were obtained from the provincial notifiable diseases surveillance system of Ain Temouchent. Using official population data, we calculated the incidence rate per 100,000 inhabitants.
Results: From 2014 to 2019, 599 cases of brucellosis cases were notified in Ain Temouchent province (mean annual incidence: 26.37 cases/100,000 inhabitants). The yearly notification peaked in 2014 (n=170 cases). The highest incidence was reported for males (56%) compared to females (44%) with a sex ratio of 1.29. Regarding age, the highest incidence of notified cases for brucellosis was in the group aged 25-44 years and over, accounting for 37,73% of all notified cases. The lowest incidence was found in the age group between 0-14 years with 11.52%. The disease peaked in May with 139 cases. The geographical distribution indicated that the highest risk area of human brucellosis was Hammam Bou Hadjar and Ain Larabaa region.
Conclusion: Our findings showed a high prevalence of human brucellosis in Ain Témouchent, with gender, age, and seasonal changes as the main risk factors for human brucellosis.

Highlights

Mohammed Bouamra (Google Scholar)

Keywords

  1. Singh BB, Khatkar MS, Aulakh RS, Gill JPS, Dhand NK. Estimation of the health and economic burden of human Brucellosis in India. Prev Vet Med. 2018; 154:148-155. doi: 10.1016/j.prevetmed.2018.03.023. PMID: 29685439.
  2. González-Espinoza G, Arce-Gorvel V, Mémet S, Gorvel JP. Brucella: reservoirs and niches in animals and humans. Pathogens. 2021;10(2):186. doi: 10.3390/pathogens10020186. PMID: 335 PMCID: PMC7915599.
  3. Ibrahim HH, Rouby S, Menshawy A, Ghazy N. Seroprevalence of camel brucellosis and molecular characterization of Brucella melitensis recovered from dromedary camels in Egypt. Res J Vet Pract. 2016; 4:17- doi: 10.14737/journal.rjvp/2016/4.1.17.24.
  4. Musallam I, Abo-Shehada M, Hegazy Y, Holt H, Guitian F. Systematic review of brucellosis in the Middle East: disease frequency in ruminants and humans and risk factors for human infection. Epidemiol Infect. 2016; 144:671–685. doi: 10.14737/journal.rjvp/2016/4.1.17.24. PMID: 26508323.
  5. Franc K, Krecek R, Häsler B, Arenas-Gamboa A. Brucellosis remains a neglected disease in the developing world: a call for interdisciplinary action. BMC Public Health. 2018; 18:125. doi: 10.1186/s12889-017-5016-y.
  6. Kazemi S, Mirzaei R, Sholeh M, Karampoor S, Keramat F, Saidijam M, Alikhani MY. microRNAs in human brucellosis: a promising therapeutic approach and biomarker for diagnosis and treatment. Immun Inflamm Dis. 2021; 9(4):1209–18. doi: 10.1002/iid3.519. PMID: 34449979.
  7. Shahzad A, Khan A, Khan MZ, Saqib M. Seroprevalence and molecular investigation of brucellosis in camels of selected districts of Punjab, Pakistan. Thai J Vet Med. 2017; 47:207-215. doi: 10.56808/2985-1130.2824.
  8. Enkelmann J, Stark K, Faber M. Epidemiological trends of notified human brucellosis in Germany, 2006-2018. Int J Infect Dis. 2020; 93:353-358. doi: 10.1016/j.ijid.2020.02.019 . PMID: 32081773.
  9. Kaynak-Onurdag F, Okten S, Sen B. Screening Brucella spp. in bovine raw milk by real-time quantitative PCR and conventional methods in a pilot region of vaccination, Edirne, Turkey. J. Dairy Sci. 2016; 99: 3351–3357. doi: 10.3168/jds.2015-10637. PMID: 26971148.
  10. Dadar M, Shahali Y, Whatmore AM. Human brucellosis caused by raw dairy products: A review on the occurrence, major risk factors and prevention. Int J Food Microbiol. 2019; 2:39-47. doi:10.1016/j.ijfoodmicro.2018.12.009.
  11. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006; 6:91-9. doi: 10.1016/s1473-3099(06)70382-6. PMID: 16439329.
  12. Niaz S, Raqeeb A, Khan A, Nasreen, Amir S, Zhu L, Kumar S. Status of human brucellosis in district Malakand, Khyber Pakhtunkhwa, Pakistan. J Infect Public Health. 2021;14(3):423-427. doi: 10.1016/j.jiph.2019.12.013.
  13. Kardjadj M. The epidemiology of human and animal brucellosis in Algeria. J Bacteriol Mycol. 2016;3(2):1025.
  14. Ammam A, Belmamoun A.R, Grele K. Prevalence of Human Brucellosis in the Southern Zone of Sidi- Bel-Abbès, Algeria. Arch Clin Med Case Rep. 2018; 2:56-64.
  15. Khamassi Khbou M, Htira S, Harabech K, Benzarti M. First case-control study of zoonotic brucellosis in Gafsa district, Southwest Tunisia. One Health. 2017;19(5):21-26. doi: 10.1016/j.onehlt.2017.12.001. PMID: 29911160.
  16. Facciolà A, Palamara MA, D’Andrea G, Marano F, Magliarditi D, Puglisi G, Picerno I, Di Pietro A, Visalli G. Brucellosis is a public health problem in southern Italy: Burden and epidemiological trend of human and animal disease. J Infect Public Health. 2018; 11:861-866. doi: 10.1016/j.jiph.2018.07.007.
  17. Ahmed MO, Elmeshri SE, Abuzweda AR, Blauo M, Abouzeed YM, Ibrahim A, Salem H, Alzwam F, Abid S, Elfahem A, Elrais A. Seroprevalence of brucellosis in animals and human populations in the western mountains region in Libya, December 2006–January 2008. Eurosurveillance. 2010;15(30). doi: 10.2807/ese.15.30.19625-en.. PMID: 20684813.
  18. Ali S, Nawaz Z, Akhtar A, Aslam R, Zahoor MA, Ashraf M. Epidemiological Investigation of Human Brucellosis in Pakistan. Jundishapur J Microbiol. 2018 ;11(7). doi: 10.5812/jjm.61764.
  19. Nematollahi S, Ayubi E, Karami M, Khazaei S, Shojaeian M, Zamani R, Mansori K, Gholamaliee B. Epidemiological characteristics of human brucellosis in Hamadan Province during 2009–2015: results from the National Notifiable Diseases Surveillance System. Int J Infect Dis .2017; 61:56-61. doi: 10.1016/j.ijid.2017.06.002
  20. Elfaki MG, Alaidan AA, Al-Hokail AA. Host response to Brucella infection: review and future perspective. J Infect Dev Ctries. 2015; 9(7):697-701. doi: 10.3855/jidc.6625. PMID: 26230118.
  21. Khazaei S, Solgi M, Goodarzi S, Khazaei L, Salehi I, Jenabi E. Epidemiology of human brucellosis in Nahavand county, Hamadan Province, western Iran: an 8-year (2010–2017) registry-based analysis. Asian Biomed. 2020; 14:151-158. doi: 10.1515/abm-2020-0022.
  22. Li D, Li L, Zhai J, Wang L, Zhang B. Epidemiological features of human brucellosis in Tongliao City, Inner Mongolia province, China: a cross-sectional study over an 11-year period (2007-2017). BMJ Open. 2020; 2: 10(1): e031206. doi: 10.1136/bmjopen-2019-031206. PMID: 31900267.
  23. Avdikou I, Maipa V, Alamanos Y. Epidemiology of human brucellosis in a defined area of Northwestern Greece. Epidemiol Infect. 2005; 133:905-10. doi: 10.1017/s0950268805003973. PMID: 16181512.
  24. Alkahtani AM, Assiry MM, Chandramoorthy HC, Al-Hakami AM, Hamid ME. Sero-prevalence and risk factors of brucellosis among suspected febrile patients attending a referral hospital in southern Saudi Arabia (2014-2018). BMC Infect Dis. 2020; 20:26. doi: 10.1186/s12879-020-4763-z.
  25. Li YJ, Li XL, Liang S, Fang LQ, Cao WC. Epidemiological features and risk factors associated with the spatial and temporal distribution of human brucellosis in China. BMC Infect Dis. 2013; 13:547. doi: 10.1186/1471-2334-13-547.